National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Amphotericin B Deoxycholate
Synonyms

Amphotericin B-deoxycholate

Amphotericin B Deoxycholate

Fungizone
Definitions

The deoxycholate salt of amphotericin B, a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane. This results in depolarization of the cell membrane, alterations in cell membrane permeability, leakage of important intracellular components, and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62201
CAS_Registry

58501-21-6
code

C62201
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424
DEFINITION

The deoxycholate salt of amphotericin B, a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane. This results in depolarization of the cell membrane, alterations in cell membrane permeability, leakage of important intracellular components, and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.
FULL_SYN

Amphotericin B-deoxycholate

Amphotericin B Deoxycholate

Fungizone
Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C238
label

Amphotericin B Deoxycholate
Legacy Concept Name

Amphotericin_B_Deoxycholate
NCI_Drug_Dictionary_ID

39143
PDQ_Closed_Trial_Search_ID

39143
PDQ_Open_Trial_Search_ID

39143
Preferred_Name

Amphotericin B Deoxycholate
prefixIRI

Thesaurus:C62201
Semantic_Type

Organic Chemical

Antibiotic
UMLS_CUI

C0051761
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C514
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