National Cancer Institute Thesaurus

Last uploaded: February 25, 2019
Preferred Name

Tamoxifen

Synonyms

tamoxifen

1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene

TAMOXIFEN

Tamoxifen

Definitions

An antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62078

ALT_DEFINITION

A drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. Tamoxifen is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Tamoxifen is a type of antiestrogen.

CAS_Registry

10540-29-1

CHEBI_ID

CHEBI:41774

Chemical_Formula

C26H29NO

code

C62078

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

An antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth.

Display_Name

Tamoxifen

FDA_UNII_Code

094ZI81Y45

FULL_SYN

tamoxifen

1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene

TAMOXIFEN

Tamoxifen

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C855

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38361

label

Tamoxifen

Legacy_Concept_Name

Tamoxifen_Base

Preferred_Name

Tamoxifen

prefixIRI

ncit:C62078

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0039286

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1821

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2089

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http://www.drugbank.ca/drugs/DB00675 FTC LOOM
http://purl.bioontology.org/ontology/NDDF/004826 NDDF LOOM
http://purl.bioontology.org/ontology/RXNORM/10324 RXNORM LOOM
http://purl.bioontology.org/ontology/RXNORM/10324 NLMVS LOOM
http://purl.bioontology.org/ontology/UATC/L02BA01 ATC LOOM
http://purl.bioontology.org/ontology/SNMI/C-781E0 SNMI LOOM
http://www.gamuts.net/entity#tamoxifen GAMUTS LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/75959001 SNOMEDCT LOOM
http://d-nb.info/gnd/4184395-2 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/RCD/he4.. RCD LOOM
http://purl.bioontology.org/ontology/LNC/LA14344-8 LOINC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373345002 SNOMEDCT LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148024 ODAE LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013629 RH-MESH LOOM
http://www.bioontology.org/pma.owl#PMA_1416 PMA LOOM
http://purl.jp/bio/4/id/200906003583642183 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_41774 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_41774 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_41774 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_41774 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_41774 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_41774 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_41774 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_41774 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_41774 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_41774 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_41774 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_41774 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_41774 HINO LOOM
http://purl.obolibrary.org/obo/CHEBI_41774 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_41774 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_41774 NIFSTD LOOM
http://purl.bioontology.org/ontology/CSP/0119-1179 CRISP LOOM
http://purl.bioontology.org/ontology/MESH/D013629 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.150.700.900 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Tamoxifen GALEN LOOM
http://www.projecthalo.com/aura#Tamoxifen AURA LOOM
http://purl.bioontology.org/ontology/VANDF/4019939 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/LP18484-3 LOINC LOOM
http://purl.org/obo/owl/CHEBI#CHEBI_41774 NPO LOOM
http://www.ifomis.org/acgt/1.0#Tamoxifen ACGT-MO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003102 LOINC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148024 NDFRT LOOM