loading...| Preferred Name |
Quinapril |
|
| Synonyms |
QUINAPRIL Quinapril |
|
| Definitions |
A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril is hydrolized into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. Quinapril also causes a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62074 |
|
| CAS_Registry |
85441-61-8 |
|
| CHEBI_ID |
CHEBI:8713 |
|
| Chemical_Formula |
C25H30N2O5 |
|
| code |
C62074 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril is hydrolized into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. Quinapril also causes a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels. |
|
| FDA_UNII_Code |
RJ84Y44811 |
|
| FULL_SYN |
QUINAPRIL Quinapril |
|
| Has_Salt_Form | ||
| label |
Quinapril |
|
| Legacy Concept Name |
Quinapril_Base |
|
| Preferred_Name |
Quinapril |
|
| prefixIRI |
Thesaurus:C62074 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0072857 |
|
| subClassOf |