National Cancer Institute Thesaurus

Last uploaded: February 4, 2019
Preferred Name

Pravastatin

Synonyms

PRAVASTATIN

[1S-[1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha]]-1,2,6,7,8,8a-Hexahydro-beta,!d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid

pravastatin

Pravastatin

Definitions

A synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62070

ALT_DEFINITION

The active ingredient in a drug used to lower the amount of cholesterol in the blood and to prevent stroke and heart attack. It is also being studied in the treatment of cancer and other conditions. Pravastatin blocks an enzyme that helps make cholesterol in the body. It may also make tumor cells more sensitive to anticancer drugs. It is a type of HMG-CoA reductase inhibitor, a type of statin, and a type of chemosensitizer.

CAS_Registry

81093-37-0

CHEBI_ID

CHEBI:63618

Chemical_Formula

C23H36O7

code

C62070

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)

FDA_UNII_Code

KXO2KT9N0G

FULL_SYN

PRAVASTATIN

[1S-[1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha]]-1,2,6,7,8,8a-Hexahydro-beta,!d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid

pravastatin

Pravastatin

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29375

label

Pravastatin

Legacy_Concept_Name

Pravastatin_Base

Preferred_Name

Pravastatin

prefixIRI

ncit:C62070

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0085542

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1655

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http://purl.jp/bio/4/id/200906093225057464 IOBC LOOM
http://scai.fraunhofer.de/AlzheimerOntology#pravastatin ADO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148255 NDFRT LOOM
http://www.drugbank.ca/drugs/DB00175 FTC LOOM
http://purl.bioontology.org/ontology/LNC/LP171630-9 LOINC LOOM
http://purl.bioontology.org/ontology/UATC/C10AA03 ATC LOOM
http://purl.bioontology.org/ontology/NDDF/003606 NDDF LOOM
http://purl.bioontology.org/ontology/VANDF/4020548 VANDF LOOM
http://purl.bioontology.org/ontology/RCD/x01R3 RCD LOOM
http://d-nb.info/gnd/4255787-2 FAST-TOPICAL LOOM
http://www.co-ode.org/ontologies/galen#Pravastatin GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.847.638.930 RH-MESH LOOM
http://www.semanticweb.org/ontologies/STO.owl#a5dcdea_0bdd_4060_bda4_ef53c4ecb067 CVAO LOOM
http://www.semanticweb.org/ontologies/STO.owl#a5dcdea_0bdd_4060_bda4_ef53c4ecb067 STO-DRAFT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.638.930 RH-MESH LOOM
http://doe-generated-ontology.com/OntoAD#C0085542 ONTOAD LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373566006 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D017035 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/96305006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/MESH/D017035 MESH LOOM
http://www.owl-ontologies.com/OntologyXCT.owl#Pravastatin CTX LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000424450 PDQ LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148255 ODAE LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148255 OCVDAE LOOM
http://purl.bioontology.org/ontology/RXNORM/42463 RXNORM LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005336 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005336 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005336 DMTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004007 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004007 DMTO LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 CHEBI LOOM
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http://purl.obolibrary.org/obo/CHEBI_63618 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 DINTO LOOM
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http://purl.obolibrary.org/obo/CHEBI_63618 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 FYPO LOOM
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http://purl.obolibrary.org/obo/CHEBI_63618 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_63618 GO-PLUS LOOM
http://purl.bioontology.org/ontology/SNMI/C-80820 SNMI LOOM