loading...| Preferred Name |
Pilocarpine |
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| Synonyms |
Ocusert Pilo pilocarpine PILOCARPINE Pilocarpine |
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| Definitions |
A natural alkaloid extracted from plants of the genus Pilocarpus with cholinergic agonist activity. As a cholinergic parasympathomimetic agent, pilocarpine predominantly binds to muscarinic receptors, thereby inducing exocrine gland secretion and stimulating smooth muscle in the bronchi, urinary tract, biliary tract, and intestinal tract. When applied topically to eyes, this agent stimulates the sphincter pupillae to contract, resulting in miosis; stimulates the ciliary muscle to contract, resulting in spasm of accommodation; and may cause a transitory rise in intraocular pressure followed by a more persistent fall due to opening of the trabecular meshwork and an increase in the outflow of aqueous humor. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62068 |
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| ALT_DEFINITION |
A drug used to increase salivation in people who have dry mouth caused by opioids or radiation therapy. Pilocarpine belongs to the family of drugs called alkaloids. |
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| CAS_Registry |
92-13-7 |
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| CHEBI_ID |
CHEBI:8207 |
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| Chemical_Formula |
C11H16N2O2 |
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| code |
C62068 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
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| DEFINITION |
A natural alkaloid extracted from plants of the genus Pilocarpus with cholinergic agonist activity. As a cholinergic parasympathomimetic agent, pilocarpine predominantly binds to muscarinic receptors, thereby inducing exocrine gland secretion and stimulating smooth muscle in the bronchi, urinary tract, biliary tract, and intestinal tract. When applied topically to eyes, this agent stimulates the sphincter pupillae to contract, resulting in miosis; stimulates the ciliary muscle to contract, resulting in spasm of accommodation; and may cause a transitory rise in intraocular pressure followed by a more persistent fall due to opening of the trabecular meshwork and an increase in the outflow of aqueous humor. |
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| FDA_UNII_Code |
01MI4Q9DI3 |
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| FULL_SYN |
Ocusert Pilo pilocarpine PILOCARPINE Pilocarpine |
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| Has_Salt_Form | ||
| label |
Pilocarpine |
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| Legacy Concept Name |
Pilocarpine_Base |
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| Preferred_Name |
Pilocarpine |
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| prefixIRI |
Thesaurus:C62068 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0031923 |
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| subClassOf |