Preferred Name |
Phentolamine |
|
Synonyms |
PHENTOLAMINE 2-[N-p'-Tolyl-N-(m'-hydroxyphenyl)aminomethyl]imidazoline Phentolamine |
|
Definitions |
A synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62066 |
|
CAS_Registry |
50-60-2 |
|
Chemical_Formula |
C17H19N3O |
|
code |
C62066 |
|
Concept_In_Subset | ||
Contributing_Source |
FDA |
|
DEFINITION |
A synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. |
|
FDA_UNII_Code |
Z468598HBV |
|
FULL_SYN |
PHENTOLAMINE 2-[N-p'-Tolyl-N-(m'-hydroxyphenyl)aminomethyl]imidazoline Phentolamine |
|
Has_Salt_Form | ||
label |
Phentolamine |
|
Legacy Concept Name |
Phentolamine_Base |
|
Preferred_Name |
Phentolamine |
|
prefixIRI |
Thesaurus:C62066 |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0031448 |
|
subClassOf |