National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Nortriptyline

Synonyms

Nortriptyline

NORTRIPTYLINE

Definitions

A tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62060

CAS_Registry

72-69-5

CHEBI_ID

CHEBI:7640

Chemical_Formula

C19H21N

code

C62060

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors.

FDA_UNII_Code

BL03SY4LXB

FULL_SYN

Nortriptyline

NORTRIPTYLINE

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C704

label

Nortriptyline

Legacy_Concept_Name

Nortriptyline_Base

Preferred_Name

Nortriptyline

prefixIRI

ncit:C62060

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0028420

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94727

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http://www.case.edu/EpSO.owl#Nortriptyline EPSO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372652004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/CSP/0780-7274 CRISP LOOM
http://purl.bioontology.org/ontology/UATC/N06AA10 ATC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147946 ODAE LOOM
http://stirdf.jst.go.jp/id/200907065269822397 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP14984-6 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/7531 RXNORM LOOM
http://www.drugbank.ca/drugs/DB00540 FTC LOOM
http://purl.bioontology.org/ontology/NDDF/004601 NDDF LOOM
http://bmi.utah.edu/ontologies/hfontology/C0028420 HFO LOOM
http://purl.jp/bio/4/id/200906035215708610 IOBC LOOM
http://scai.fraunhofer.de/AlzheimerOntology#nortriptyline ADO LOOM
http://purl.bioontology.org/ontology/MESH/D009661 MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU005025 LOINC LOOM
http://purl.bioontology.org/ontology/SNMI/C-622C0 SNMI LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004284 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004284 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004284 DMTO LOOM
http://www.co-ode.org/ontologies/galen#Nortriptyline GALEN LOOM
http://purl.bioontology.org/ontology/RCD/d7c.. RCD LOOM
http://purl.bioontology.org/ontology/VANDF/4019860 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.847.181.384.535 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147946 NDFRT LOOM
http://purl.obolibrary.org/obo/CHEBI_7640 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_7640 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_7640 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_7640 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_7640 NIFSTD LOOM
http://purl.obolibrary.org/obo/dinto_DB00540 DINTO LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Nortriptyline APAONTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D009661 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.181.384.535 RH-MESH LOOM