loading...| Preferred Name |
Mechlorethamine |
|
| Synonyms |
MECHLORETHAMINE Mechlorethamine chloromethine Chlormethine Nitrogen Mustard Chlorethazine chlorethazine Bis(2-chloroethyl)methylamine ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl NITROGEN MUSTARD HN-2 Methylbis(beta-chloroethyl)amine methylchlorethamine HN 2 HN2 Mustard Mustine |
|
| Definitions |
A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62056 |
|
| ALT_DEFINITION |
The nitrogen mustard vesicant HN-2. |
|
| CAS_Registry |
51-75-2 |
|
| CHEBI_ID |
CHEBI:28925 |
|
| Chemical_Formula |
C5H11Cl2N |
|
| code |
C62056 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77526 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C160930 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
|
| Contributing_Source |
CDISC FDA GDC HemOnc PCDC |
|
| DEFINITION |
A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04) |
|
| FDA_UNII_Code |
50D9XSG0VR |
|
| FULL_SYN |
MECHLORETHAMINE Mechlorethamine chloromethine Chlormethine Nitrogen Mustard Chlorethazine chlorethazine Bis(2-chloroethyl)methylamine ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl NITROGEN MUSTARD HN-2 Methylbis(beta-chloroethyl)amine methylchlorethamine HN 2 HN2 Mustard Mustine |
|
| Has_Salt_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Mechlorethamine |
|
| Legacy Concept Name |
Mechlorethamine |
|
| Maps_To |
Mechlorethamine |
|
| Preferred_Name |
Mechlorethamine |
|
| prefixIRI |
Thesaurus:C62056 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0025033 |
|
| subClassOf |