National Cancer Institute Thesaurus

Last uploaded: December 30, 2019
Preferred Name

Mechlorethamine

Synonyms

ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl

Mustard

chloromethine

HN2

Methylbis(beta-chloroethyl)amine

chlorethazine

MECHLORETHAMINE

NITROGEN MUSTARD HN-2

Chlorethazine

Chlormethine

HN 2

Mustine

Nitrogen Mustard

Mechlorethamine

methylchlorethamine

Bis(2-chloroethyl)methylamine

Definitions

A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62056

ALT_DEFINITION

The nitrogen mustard vesicant HN-2.

CAS_Registry

51-75-2

CHEBI_ID

CHEBI:28925

Chemical_Formula

C5H11Cl2N

code

C62056

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C160930

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77526

Contributing_Source

CDISC

FDA

DEFINITION

A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04)

FDA_UNII_Code

50D9XSG0VR

FULL_SYN

ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl

Mustard

chloromethine

HN2

Methylbis(beta-chloroethyl)amine

chlorethazine

MECHLORETHAMINE

NITROGEN MUSTARD HN-2

Chlorethazine

Chlormethine

HN 2

Mustine

Nitrogen Mustard

Mechlorethamine

methylchlorethamine

Bis(2-chloroethyl)methylamine

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C627

label

Mechlorethamine

Legacy_Concept_Name

Mechlorethamine

Preferred_Name

Mechlorethamine

prefixIRI

ncit:C62056

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0025033

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C697

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http://purl.obolibrary.org/obo/CHEBI_28925 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28925 FYPO LOOM
http://purl.bioontology.org/ontology/RXNORM/6674 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372692002 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/dinto_DB00888 DINTO LOOM
http://purl.bioontology.org/ontology/MESH/D008466 MESH LOOM
http://purl.bioontology.org/ontology/CSP/1371-8974 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.526.728.650.529 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#7827 OCHV LOOM
http://purl.bioontology.org/ontology/VANDF/4019808 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147897 NDFRT LOOM
http://purl.obolibrary.org/obo/DRON_00015910 DRON LOOM
http://purl.jp/bio/4/id/200906006617941281 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0025033 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008466 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-78130 SNMI LOOM