National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Naloxone

Synonyms

(-)-Naloxone

NALOXONE

Naloxone

naloxone

Definitions

A thebaine derivate with competitive opioid antagonistic properties. Naloxone reverses the effects of opioid analgesics by binding to the opioid receptors in the CNS, and inhibiting the typical actions of opioid analgesics, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. Naloxone binds to mu-opioid receptors with a high affinity, and a lesser degree to kappa- and gamma-opioid receptors in the CNS.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62054

ALT_DEFINITION

A substance that is being studied as a treatment for constipation caused by narcotic medications. It belongs to the family of drugs called narcotic antagonists.

CAS_Registry

465-65-6

CHEBI_ID

CHEBI:7459

Chemical_Formula

C19H21NO4

code

C62054

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A thebaine derivate with competitive opioid antagonistic properties. Naloxone reverses the effects of opioid analgesics by binding to the opioid receptors in the CNS, and inhibiting the typical actions of opioid analgesics, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. Naloxone binds to mu-opioid receptors with a high affinity, and a lesser degree to kappa- and gamma-opioid receptors in the CNS.

FDA_UNII_Code

36B82AMQ7N

FULL_SYN

(-)-Naloxone

NALOXONE

Naloxone

naloxone

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C678

label

Naloxone

Legacy Concept Name

Naloxone_Base

Preferred_Name

Naloxone

prefixIRI

Thesaurus:C62054

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0027358

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C681

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/RCD/x01GS RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D009270 RH-MESH LOOM
http://www.gamuts.net/entity#naloxone GAMUTS LOOM
http://purl.bioontology.org/ontology/LNC/MTHU013159 LOINC LOOM
http://purl.bioontology.org/ontology/VANDF/4019852 VANDF LOOM
http://purl.obolibrary.org/obo/OMIT_0010304 OMIT LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Naloxone APAONTO LOOM
http://purl.jp/bio/4/id/200906017818062334 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.549.686.750 RH-MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C62054 BERO LOOM
http://purl.bioontology.org/ontology/LNC/LP28525-1 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#8472 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.132.577.249.706 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/7242 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.615.723.795.706 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907083987497672 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0027358 OCHV LOOM
http://www.co-ode.org/ontologies/galen#Naloxone GALEN LOOM
http://purl.bioontology.org/ontology/SNMI/C-60D10 SNMI LOOM
https://go.drugbank.com/drugs/DB01183 MDM LOOM
http://purl.obolibrary.org/obo/MESH_D009270 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_7459 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_7459 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_7459 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_7459 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_7459 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_7459 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_7459 NIFSTD LOOM
http://purl.bioontology.org/ontology/ATC/A06AH04 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147938 NDFRT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018044 PMAPP-PMO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.605.497.750 RH-MESH LOOM
http://purl.obolibrary.org/obo/SCDO_0000789 SCDO LOOM
http://www.drugbank.ca/drugs/DB01183 FTC LOOM
http://purl.bioontology.org/ontology/MESH/D009270 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372890007 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/ATC/V03AB15 ATC LOOM
http://purl.bioontology.org/ontology/CSP/0092-8381 CRISP LOOM