National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Metoclopramide

Synonyms

Metoclopramide

metoclopramide

METOCLOPRAMIDE

Definitions

A substituted benzamide and a derivative of para-aminobenzoic acid (PABA) that is structurally related to procainamide, with gastroprokinetic and antiemetic effects. Metoclopramide exerts its prokinetic effect by antagonizing dopamine mediated relaxation effect on gastrointestinal smooth muscle. This enhances the response of the gastrointestinal smooth muscle to cholinergic stimulation, thereby leading to an increase of gastric emptying into the intestines. Metoclopramide may also strengthen the lower esophagus sphincter, thereby preventing acid reflux. This agent antagonizes D2 dopamine receptors in chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and vomiting.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62046

ALT_DEFINITION

A drug that increases the motility (movements and contractions) of the stomach and upper intestine. It is used to treat certain stomach problems and nausea and vomiting caused by chemotherapy. It is a type of antiemetic and a type of motility agent.

CAS_Registry

364-62-5

CHEBI_ID

CHEBI:107736

Chemical_Formula

C14H22ClN3O2

code

C62046

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A substituted benzamide and a derivative of para-aminobenzoic acid (PABA) that is structurally related to procainamide, with gastroprokinetic and antiemetic effects. Metoclopramide exerts its prokinetic effect by antagonizing dopamine mediated relaxation effect on gastrointestinal smooth muscle. This enhances the response of the gastrointestinal smooth muscle to cholinergic stimulation, thereby leading to an increase of gastric emptying into the intestines. Metoclopramide may also strengthen the lower esophagus sphincter, thereby preventing acid reflux. This agent antagonizes D2 dopamine receptors in chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and vomiting.

Display_Name

Metoclopramide

FDA_UNII_Code

L4YEB44I46

FULL_SYN

Metoclopramide

metoclopramide

METOCLOPRAMIDE

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C649

label

Metoclopramide

Legacy_Concept_Name

Metoclopramide_Base

Preferred_Name

Metoclopramide

prefixIRI

ncit:C62046

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0025853

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C267

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http://purl.obolibrary.org/obo/CHEBI_107736 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_107736 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_107736 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_107736 CHEBI LOOM
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