loading...| Preferred Name |
Hydromorphone |
|
| Synonyms |
HYDROMORPHONE Dihydromorphinone hydromorphone (-)-Hydromorphone Hydromorphon Hydromorphone |
|
| Definitions |
The hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62034 |
|
| ALT_DEFINITION |
A drug used to relieve pain. |
|
| CAS_Registry |
466-99-9 |
|
| CHEBI_ID |
CHEBI:5790 |
|
| Chemical_Formula |
C17H19NO3 |
|
| code |
C62034 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
The hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons. |
|
| Display_Name |
Hydromorphone |
|
| FDA_UNII_Code |
Q812464R06 |
|
| FULL_SYN |
HYDROMORPHONE Dihydromorphinone hydromorphone (-)-Hydromorphone Hydromorphon Hydromorphone |
|
| Has_Salt_Form | ||
| label |
Hydromorphone |
|
| Legacy Concept Name |
Hydromorphone_Base |
|
| Preferred_Name |
Hydromorphone |
|
| prefixIRI |
Thesaurus:C62034 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0012306 |
|
| subClassOf |