National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Dopamine

Synonyms

Dopamine

DOPAMINE

Definitions

A monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62025

CAS_Registry

51-61-6

CHEBI_ID

CHEBI:18243

Chemical_Formula

C8H11NO2

code

C62025

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output.

FDA_UNII_Code

VTD58H1Z2X

FULL_SYN

Dopamine

DOPAMINE

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C455

label

Dopamine

Legacy_Concept_Name

Dopamine_Base

Preferred_Name

Dopamine

prefixIRI

ncit:C62025

Semantic_Type

Biologically Active Substance

UMLS_CUI

C0013030

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88516

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http://purl.bioontology.org/ontology/LNC/MTHU004130 LOINC LOOM
http://purl.obolibrary.org/obo/IMR_0100113 TXPO LOOM
http://purl.obolibrary.org/obo/IMR_0100113 TXPO LOOM
http://purl.jp/bio/4/id/200906066432770661 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004298 RH-MESH LOOM
http://purl.bioontology.org/ontology/CSP/2268-5256 CRISP LOOM
http://purl.bioontology.org/ontology/RCD/x01D5 RCD LOOM
http://www.bioontology.org/pma.owl#PMA_196 PMA LOOM
http://purl.bioontology.org/ontology/MESH/D004298 MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP15543-9 LOINC LOOM
http://purl.obolibrary.org/obo/UPa_UPC03758 UPA LOOM
http://bmi.utah.edu/ontologies/hfontology/C0013030 HFO LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Dopamine APANEUROCLUSTER LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Dopamine APAONTO LOOM
http://id.loc.gov/authorities/subjects/sh85039075 FAST-TOPICAL LOOM
http://purl.org/sig/ont/fma/fma67238 FMA LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.311.342 RH-MESH LOOM
http://www.bioassayontology.org/bao#BAO_0000894 BAO LOOM
http://localhost/plosthes.2017-1#4300 PLOSTHES LOOM
http://purl.obolibrary.org/obo/CHEBI_18243 DTO LOOM
http://purl.obolibrary.org/obo/CHEBI_18243 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_18243 CLO LOOM
http://purl.obolibrary.org/obo/CHEBI_18243 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_18243 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_18243 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_18243 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_18243 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_18243 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_18243 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_18243 ZP LOOM
http://purl.obolibrary.org/obo/CHEBI_18243 HINO LOOM
http://purl.obolibrary.org/obo/CHEBI_18243 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_18243 OBA LOOM
http://purl.bioontology.org/ontology/RXNORM/3628 RXNORM LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147825 OCVDAE LOOM
http://www.drugbank.ca/drugs/DB00988 FTC LOOM
http://www.co-ode.org/ontologies/galen#Dopamine GALEN LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/412383006 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.211.215.311.342 RH-MESH LOOM
http://scai.fraunhofer.de/MSOntology#Dopamine MSO LOOM
http://purl.bioontology.org/ontology/LNC/LA16923-7 LOINC LOOM
http://data.bnf.fr/ark:/12148/cb11971135g FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147825 NDFRT LOOM
http://purl.org/obo/owlapi/fma#FMA_67238 BIOMODELS LOOM
http://ccdb.ucsd.edu/SAO/1.2#sao2050279787 SAO LOOM
http://purl.bioontology.org/ontology/SNMI/F-B2140 SNMI LOOM
http://protegeuserexample#Dopamine PDON LOOM
http://stirdf.jst.go.jp/id/200907040711265386 IOBC LOOM
http://bmi.utah.edu/ontologies/peontology/C0013030 PE LOOM
http://purl.bioontology.org/ontology/VANDF/4019733 VANDF LOOM
http://www.projecthalo.com/aura#Dopamine AURA LOOM
http://purl.bioontology.org/ontology/UATC/C01CA04 ATC LOOM
http://www.semanticweb.org/tome/ontologies/2015/7/Richfields#dopamine ISO-FOOD LOOM
http://doe-generated-ontology.com/OntoAD#C0013030 ONTOAD LOOM