National Cancer Institute Thesaurus

Last uploaded: June 25, 2019
Preferred Name

Cephalothin

Synonyms

Cephalothin

CEPHALOTHIN

Definitions

A semisynthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalothin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62021

CAS_Registry

153-61-7

CHEBI_ID

CHEBI:124991

Chemical_Formula

C16H16N2O6S2

code

C62021

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A semisynthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalothin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

FDA_UNII_Code

R72LW146E6

FULL_SYN

Cephalothin

CEPHALOTHIN

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C358

label

Cephalothin

Legacy_Concept_Name

Cephalothin_Base

Preferred_Name

Cephalothin

prefixIRI

ncit:C62021

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0007735

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.249.190.210 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU006525 LOINC LOOM
http://purl.bioontology.org/ontology/MESH/D002512 MESH LOOM
http://purl.jp/bio/4/id/200906044880087308 IOBC LOOM
http://purl.obolibrary.org/obo/DRON_00010446 DRON LOOM
http://purl.bioontology.org/ontology/LNC/LP15270-9 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/2236 RXNORM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147761 NDFRT LOOM
http://stirdf.jst.go.jp/id/200907007956580638 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4019669 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.665.074.190.210 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-53140 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.249.190.210 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373485007 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDDF/004840 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002512 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/e6a.. RCD LOOM