National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Ceftriaxone

Synonyms

CEFTRIAXONE

ceftriaxone

Ceftriaxone

Definitions

A beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftriaxone binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftriaxone is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftriaxone also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS).

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62020

ALT_DEFINITION

An antibiotic drug used to treat infection. It belongs to the family of drugs called cephalosporin antibiotics.

CAS_Registry

73384-59-5

CHEBI_ID

CHEBI:29007

Chemical_Formula

C18H18N8O7S3

code

C62020

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftriaxone binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftriaxone is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftriaxone also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS).

FDA_UNII_Code

75J73V1629

FULL_SYN

CEFTRIAXONE

ceftriaxone

Ceftriaxone

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C817

label

Ceftriaxone

Legacy_Concept_Name

Ceftriaxone_Base

Preferred_Name

Ceftriaxone

prefixIRI

ncit:C62020

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0007561

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357

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http://purl.bioontology.org/ontology/NDFRT/N0000147759 NDFRT LOOM
http://purl.bioontology.org/ontology/SNMI/C-53560 SNMI LOOM
http://purl.obolibrary.org/obo/ARO_0000062 ARO LOOM
http://purl.obolibrary.org/obo/ARO_0000062 ARO LOOM
http://purl.obolibrary.org/obo/CHEBI_29007 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_29007 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_29007 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_29007 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_29007 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_29007 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_29007 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_29007 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_29007 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_29007 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_29007 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_29007 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_29007 NIFSTD LOOM
http://www.co-ode.org/ontologies/galen#Ceftriaxone GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.249.190.190.155 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/004849 NDDF LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004608 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002443 RH-MESH LOOM
http://purl.obolibrary.org/obo/XCO_0000484 XCO LOOM
http://purl.obolibrary.org/obo/XCO_0000484 XCO LOOM
http://purl.bioontology.org/ontology/UATC/J01DD04 ATC LOOM
http://purl.bioontology.org/ontology/RCD/e6m.. RCD LOOM
http://purl.jp/bio/4/id/200906009725797960 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D002443 MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4019667 VANDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#2571 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/LP15260-0 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.249.190.190.155 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907088592922597 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372670001 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.665.074.190.190.155 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/2193 RXNORM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0007561 OCHV LOOM