loading...| Preferred Name |
Lovastatin |
|
| Synonyms |
(2S)-2-Methylbutanoic Acid, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester Lovastatin Sodium Monacolin K LOVASTATIN Lovastatin Mevacor Mevinolin lovastatin |
|
| Definitions |
A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering and potential antineoplastic activities. Lovastatin is hydrolyzed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG-CoA) reductase, an enzyme involved in cholesterol biosynthesis. In addition, this agent may induce tumor cell apoptosis and inhibit tumor cell invasiveness, possibly by inhibiting protein farnesylation and protein geranylgeranylation, and may arrest cells in the G1 phase of the cell cycle. The latter effect sensitizes tumor cells to the cytotoxic effects of ionizing radiation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C620 |
|
| Accepted_Therapeutic_Use_For |
Atherosclerosis; Coronary heart disease, prevention; Hypercholesterolemia |
|
| ALT_DEFINITION |
A drug used to lower the amount of cholesterol in the blood. It is also being studied in the prevention and treatment of some types of cancer. Lovastatin is a type of HMG-CoA reductase inhibitor (statin). |
|
| CAS_Registry |
75330-75-5 |
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| CHEBI_ID |
CHEBI:40303 |
|
| Chemical_Formula |
C24H36O5 |
|
| code |
C620 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering and potential antineoplastic activities. Lovastatin is hydrolyzed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG-CoA) reductase, an enzyme involved in cholesterol biosynthesis. In addition, this agent may induce tumor cell apoptosis and inhibit tumor cell invasiveness, possibly by inhibiting protein farnesylation and protein geranylgeranylation, and may arrest cells in the G1 phase of the cell cycle. The latter effect sensitizes tumor cells to the cytotoxic effects of ionizing radiation. |
|
| Display_Name |
Lovastatin |
|
| FDA_UNII_Code |
9LHU78OQFD |
|
| FULL_SYN |
(2S)-2-Methylbutanoic Acid, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester Lovastatin Sodium Monacolin K LOVASTATIN Lovastatin Mevacor Mevinolin lovastatin |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Lovastatin |
|
| Legacy Concept Name |
Lovastatin |
|
| Maps_To |
Lovastatin |
|
| NCI_Drug_Dictionary_ID |
41658 |
|
| NSC Number |
633781 |
|
| PDQ_Closed_Trial_Search_ID |
41658 |
|
| PDQ_Open_Trial_Search_ID |
41658 |
|
| Preferred_Name |
Lovastatin |
|
| prefixIRI |
Thesaurus:C620 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0024027 |
|
| subClassOf |