National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Trandolapril

Synonyms

TRANDOLAPRIL

Trandolapril

Mavik

Definitions

A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, trandolapril is converted by de-esterification in the liver into its active form trandolaprilat. Trandolaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Trandolaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61978

CAS_Registry

87679-37-6

Chemical_Formula

C24H34N2O5

code

C61978

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, trandolapril is converted by de-esterification in the liver into its active form trandolaprilat. Trandolaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Trandolaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

FDA_UNII_Code

1T0N3G9CRC

FULL_SYN

TRANDOLAPRIL

Trandolapril

Mavik

label

Trandolapril

Legacy_Concept_Name

Trandolapril

Preferred_Name

Trandolapril

prefixIRI

ncit:C61978

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0076891

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C247

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http://purl.obolibrary.org/obo/dinto_DB00519 DINTO LOOM
http://www.drugbank.ca/drugs/DB00519 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C052035 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Trandolapril GALEN LOOM
http://purl.bioontology.org/ontology/UATC/C09AA10 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/38454 RXNORM LOOM
http://purl.bioontology.org/ontology/RXNORM/38454 NLMVS LOOM
http://purl.bioontology.org/ontology/VANDF/4020971 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_9649 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9649 CHEBI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0076891 OCHV LOOM
http://purl.bioontology.org/ontology/RCD/bi9.. RCD LOOM
http://purl.bioontology.org/ontology/NDDF/004452 NDDF LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#trandolapril SDO LOOM
http://purl.obolibrary.org/obo/DRON_00016394 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00016394 DRON LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148444 NDFRT LOOM
http://scai.fraunhofer.de/AlzheimerOntology#trandolapril ADO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14962 OCHV LOOM
http://stirdf.jst.go.jp/id/200907070351713842 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386871006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/MESH/C052035 MESH LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#trandolapril FASTO LOOM
http://bmi.utah.edu/ontologies/hfontology/C0076891 HFO LOOM
http://purl.jp/bio/4/id/200906074806220418 IOBC LOOM