National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Succimer
Synonyms

Butanedioic Acid, 2,3-Dimercapto-, (2R,3S)-rel-

Meso 2, 3-Dimercaptosuccinic Acid

Chemet

DMSA

SUCCIMER

Succimer
Definitions

An orally active mercaptodicarboxylic acid, with heavy metal chelating activity. As a strong chelator, succimer is able to bind to heavy metals, such as lead, in the bloodstream, thereby forming a water-soluble complex that can be eliminated via urinary excretion. This prevents heavy metal poisoning. In addition, succimer is able to chelate the alpha particle emitter and radionuclide polonium Po 210 ((Po-210), thereby increasing its excretion and reducing the toxic effects of Po-210.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61953
CAS_Registry

304-55-2
CHEBI_ID

CHEBI:63623
Chemical_Formula

C4H6O4S2
code

C61953
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

CTRP

FDA
DEFINITION

An orally active mercaptodicarboxylic acid, with heavy metal chelating activity. As a strong chelator, succimer is able to bind to heavy metals, such as lead, in the bloodstream, thereby forming a water-soluble complex that can be eliminated via urinary excretion. This prevents heavy metal poisoning. In addition, succimer is able to chelate the alpha particle emitter and radionuclide polonium Po 210 ((Po-210), thereby increasing its excretion and reducing the toxic effects of Po-210.
Display_Name

Succimer
FDA_UNII_Code

DX1U2629QE
FULL_SYN

Butanedioic Acid, 2,3-Dimercapto-, (2R,3S)-rel-

Meso 2, 3-Dimercaptosuccinic Acid

Chemet

DMSA

SUCCIMER

Succimer
label

Succimer
Legacy Concept Name

Succimer
NCI_Drug_Dictionary_ID

798947
PDQ_Closed_Trial_Search_ID

798947
PDQ_Open_Trial_Search_ID

798947
Preferred_Name

Succimer
prefixIRI

Thesaurus:C61953
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0012384
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C360
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Delete Mapping To Ontology Source
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61953 ENM SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63623 CHEBI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004113 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0012384 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.081.337.759.500 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3962 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D004113 MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147417 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/109104002 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/dinto_DB00566 DINTO LOOM
http://purl.bioontology.org/ontology/VANDF/4019174 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_63623 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_63623 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_63623 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00011589 ODNAE LOOM
http://purl.obolibrary.org/obo/NCIT_C61953 BERO LOOM
http://purl.obolibrary.org/obo/MESH_D004113 BERO LOOM
http://purl.bioontology.org/ontology/NDDF/003583 NDDF LOOM
https://go.drugbank.com/drugs/DB00566 MDM LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016404 PMAPP-PMO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.489.750 RH-MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0005378 OMIT LOOM
http://purl.bioontology.org/ontology/RXNORM/3446 RXNORM LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147417 ODAE LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61953 ENM LOOM