National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Rifaximin

Synonyms

RIFAXIMIN

Rifaximin

Xifaxan

Definitions

An orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting bacterial RNA synthesis and bacterial cell growth. As rifaximin is not well absorbed, its antibacterial activity is largely localized to the gastrointestinal tract.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61926

CAS_Registry

80621-81-4

Chemical_Formula

C43H51N3O11

code

C61926

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

An orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting bacterial RNA synthesis and bacterial cell growth. As rifaximin is not well absorbed, its antibacterial activity is largely localized to the gastrointestinal tract.

Display_Name

Rifaximin

FDA_UNII_Code

L36O5T016N

FULL_SYN

RIFAXIMIN

Rifaximin

Xifaxan

label

Rifaximin

Legacy Concept Name

Rifaximin

NCI_Drug_Dictionary_ID

654589

PDQ_Closed_Trial_Search_ID

654589

PDQ_Open_Trial_Search_ID

654589

Preferred_Name

Rifaximin

prefixIRI

Thesaurus:C61926

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0073374

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C258

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