National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Quetiapine

Synonyms

QUETIAPINE

Quetiapine

Definitions

A dibenzothiazepine derivative with antipsychotic property. Quetiapine fumarate antagonizes serotonin activity mediated by 5-HT 1A and 5-HT2 receptors. With a lower affinity, this agent also reversibly binds to dopamine D1 and D2 receptors in the mesolimbic and mesocortical areas of the brain leading to decreased psychotic effects, such as hallucinations and delusions. In addition, quetiapine also binds to other alpha-1, alpha-2 adrenergic and histamine H1 receptors.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61917

CAS_Registry

111974-69-7

CHEBI_ID

CHEBI:8707

Chemical_Formula

C21H25N3O2S

code

C61917

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A dibenzothiazepine derivative with antipsychotic property. Quetiapine fumarate antagonizes serotonin activity mediated by 5-HT 1A and 5-HT2 receptors. With a lower affinity, this agent also reversibly binds to dopamine D1 and D2 receptors in the mesolimbic and mesocortical areas of the brain leading to decreased psychotic effects, such as hallucinations and delusions. In addition, quetiapine also binds to other alpha-1, alpha-2 adrenergic and histamine H1 receptors.

FDA_UNII_Code

BGL0JSY5SI

FULL_SYN

QUETIAPINE

Quetiapine

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47700

label

Quetiapine

Legacy_Concept_Name

Quetiapine

Preferred_Name

Quetiapine

prefixIRI

ncit:C61917

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0123091

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29710

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66885

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http://scai.fraunhofer.de/AlzheimerOntology#Quetiapine ADO LOOM
http://stirdf.jst.go.jp/id/200907034249704611 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022085 NDFRT LOOM
http://purl.obolibrary.org/obo/CHEBI_8707 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_8707 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_8707 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8707 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_8707 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8707 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8707 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8707 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8707 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_8707 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8707 NIFSTD LOOM
http://purl.bioontology.org/ontology/LNC/MTHU012935 LOINC LOOM
http://www.co-ode.org/ontologies/galen#Quetiapine GALEN LOOM
http://purl.bioontology.org/ontology/UATC/N05AH04 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4024080 VANDF LOOM
http://purl.bioontology.org/ontology/NDDF/006939 NDDF LOOM
http://www.drugbank.ca/drugs/DB01224 FTC LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004364 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004364 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004364 DMTO LOOM
http://www.case.edu/EpSO.owl#Quetiapine EPSO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386850001 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/LP21161-2 LOINC LOOM
http://doe-generated-ontology.com/OntoAD#C0123091 ONTOAD LOOM
http://purl.jp/bio/4/id/200906075467220183 IOBC LOOM
http://purl.bioontology.org/ontology/RCD/d4s.. RCD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#16314 OCHV LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Quetiapine APAONTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005438 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005438 DMTO LOOM
http://purl.bioontology.org/ontology/RXNORM/51272 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C069541 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0123091 OCHV LOOM