National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Procaine

Synonyms

PROCAINE

Procaine

Definitions

A benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61906

CAS_Registry

59-46-1

CHEBI_ID

CHEBI:8430

Chemical_Formula

C13H20N2O2

code

C61906

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.

FDA_UNII_Code

4Z8Y51M438

FULL_SYN

PROCAINE

Procaine

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C97301

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47688

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C132291

label

Procaine

Legacy Concept Name

Procaine

Preferred_Name

Procaine

prefixIRI

Thesaurus:C61906

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0033218

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C245

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/OMIT_0012299 OMIT LOOM
http://purl.bioontology.org/ontology/ATC/S01HA05 ATC LOOM
http://purl.bioontology.org/ontology/MESH/D011343 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387238009 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/SNMI/C-6B070 SNMI LOOM
https://go.drugbank.com/drugs/DB00721 MDM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#10138 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.223.100.050.500.906 RH-MESH LOOM
http://purl.bioontology.org/ontology/ATC/C05AD05 ATC LOOM
http://www.drugbank.ca/drugs/DB00721 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.127.020.937.906 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003046 LOINC LOOM
http://purl.bioontology.org/ontology/NDDF/004565 NDDF LOOM
http://purl.obolibrary.org/obo/CHEBI_8430 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_8430 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8430 OBIB LOOM
http://purl.obolibrary.org/obo/CHEBI_8430 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_8430 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_8430 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8430 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8430 NIFSTD LOOM
http://purl.jp/bio/4/id/200906046832175834 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/N01BA02 ATC LOOM
http://purl.obolibrary.org/obo/MESH_D011343 BERO LOOM
http://purl.bioontology.org/ontology/RXNORM/8701 RXNORM LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016495 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/VANDF/4019905 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/LP17981-9 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0033218 OCHV LOOM
http://www.co-ode.org/ontologies/galen#Procaine GALEN LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147990 NDFRT LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Procaine APAONTO LOOM
http://purl.bioontology.org/ontology/RCD/X79Gw RCD LOOM
http://purl.bioontology.org/ontology/CSP/0129-0497 CRISP LOOM
http://purl.obolibrary.org/obo/NCIT_C61906 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011343 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907067942726284 IOBC LOOM