National Cancer Institute Thesaurus

Last uploaded: February 25, 2019
Preferred Name

Lorazepam

Synonyms

LORAZEPAM

Lorazepam

Ativan

lorazepam

7-Chloro-5-(2-chlorophenyl)-1, 3-Dihydro-3-Hydroxy-1,4- Benzodiazepin-2-one

Definitions

A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C619

ALT_DEFINITION

A drug that is used to treat anxiety and certain seizure disorders (such as epilepsy), and to prevent nausea and vomiting caused by chemotherapy. It belongs to the families of drugs called antiemetics and benzodiazepines.

CAS_Registry

846-49-1

Chemical_Formula

C15H10Cl2N2O2

code

C619

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation.

Display_Name

Lorazepam

FDA_UNII_Code

O26FZP769L

FULL_SYN

LORAZEPAM

Lorazepam

Ativan

lorazepam

7-Chloro-5-(2-chlorophenyl)-1, 3-Dihydro-3-Hydroxy-1,4- Benzodiazepin-2-one

label

Lorazepam

Legacy_Concept_Name

Lorazepam

NSC_Code

289758

PDQ_Closed_Trial_Search_ID

39757

PDQ_Open_Trial_Search_ID

39757

Preferred_Name

Lorazepam

prefixIRI

ncit:C619

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0699194

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1012

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C267

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http://purl.bioontology.org/ontology/SNMI/C-64570 SNMI LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039757 PDQ LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008140 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/6470 RXNORM LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_27cf392c_3718_428f_97e8_ad9b74d413b1 CVAO LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_27cf392c_3718_428f_97e8_ad9b74d413b1 STO-DRAFT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003365 LOINC LOOM
http://www.co-ode.org/ontologies/galen#Lorazepam GALEN LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/19225000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/MESH/D008140 MESH LOOM
http://purl.jp/bio/4/id/200906081111062834 IOBC LOOM
http://www.limics.fr/ontologies/ontoparonmed#Lorazepam ONTOPARON LOOM
http://www.limics.fr/ontologies/ontoparonmed#Lorazepam ONTOPARON LOOM
http://www.limics.fr/ontologies/ontoparonmed#Lorazepam ONTOPARON LOOM
http://www.drugbank.ca/drugs/DB00186 FTC LOOM
http://bmi.utah.edu/ontologies/hfontology/C0024002 HFO LOOM
http://www.case.edu/EpSO.owl#Lorazepam EPSO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387106007 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.079.080.070.450 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_6539 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6539 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_6539 CHEBI LOOM
http://purl.bioontology.org/ontology/LNC/LP16176-7 LOINC LOOM
http://purl.bioontology.org/ontology/CSP/0314-5650 CRISP LOOM
http://purl.bioontology.org/ontology/UATC/N05BA06 ATC LOOM
http://purl.bioontology.org/ontology/RCD/x02LN RCD LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Lorazepam APAONTO LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#lorazepam SDO LOOM
http://purl.bioontology.org/ontology/VANDF/4017848 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146205 NDFRT LOOM