National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Penicillin G

Synonyms

PENICILLIN G

Penicillin G

Definitions

A broad-spectrum, beta-lactam naturally occurring penicillin antibiotic with antibacterial activity. Penicillin G binds to and inactivates the penicillin binding proteins (PBPs) located inside the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and eventually causing cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61883

CAS_Registry

61-33-6

CHEBI_ID

CHEBI:18208

Chemical_Formula

C16H18N2O4S

code

C61883

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A broad-spectrum, beta-lactam naturally occurring penicillin antibiotic with antibacterial activity. Penicillin G binds to and inactivates the penicillin binding proteins (PBPs) located inside the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and eventually causing cell lysis.

FDA_UNII_Code

Q42T66VG0C

FULL_SYN

PENICILLIN G

Penicillin G

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28865

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47657

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47658

label

Penicillin G

Legacy_Concept_Name

Penicillin_G

NSC_Code

193396

Preferred_Name

Penicillin G

prefixIRI

ncit:C61883

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0030827

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1500

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http://purl.bioontology.org/ontology/SNOMEDCT/323389000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/MESH/D010400 MESH LOOM
http://purl.jp/bio/4/id/200906088890642994 IOBC LOOM
http://purl.jp/bio/4/id/200906088890642994 IOBC LOOM
http://purl.jp/bio/4/id/200906088890642994 IOBC LOOM
http://purl.jp/bio/4/id/200906088890642994 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.108.750.750 RH-MESH LOOM
http://purl.obolibrary.org/obo/UPa_UPC05551 UPA LOOM
http://livercancer.imbi.uni-heidelberg.de/ccont#CCONT_0000035 CCONT LOOM
http://purl.bioontology.org/ontology/LNC/LP16237-7 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.260.825.750 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/004977 NDDF LOOM
http://purl.bioontology.org/ontology/LNC/MTHU008467 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D010400 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4017440 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.750.750 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145828 NDFRT LOOM
http://purl.bioontology.org/ontology/RXNORM/7980 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.750.750 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.605.084.737.750 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907086515869389 IOBC LOOM
http://stirdf.jst.go.jp/id/200907086515869389 IOBC LOOM
http://stirdf.jst.go.jp/id/200907086515869389 IOBC LOOM
http://stirdf.jst.go.jp/id/200907086515869389 IOBC LOOM