loading...| Preferred Name |
Metoprolol |
|
| Synonyms |
METOPROLOL Metoprolol |
|
| Definitions |
A cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction leading to a reduction in cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thereby preventing vasoconstriction and aldosterone secretion. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61845 |
|
| CAS_Registry |
51384-51-1 |
|
| CHEBI_ID |
CHEBI:6904 |
|
| Chemical_Formula |
C15H25NO3 |
|
| code |
C61845 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction leading to a reduction in cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thereby preventing vasoconstriction and aldosterone secretion. |
|
| Display_Name |
Metoprolol |
|
| FDA_UNII_Code |
GEB06NHM23 |
|
| FULL_SYN |
METOPROLOL Metoprolol |
|
| Has_Salt_Form |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66133 |
|
| Has_Target | ||
| label |
Metoprolol |
|
| Legacy Concept Name |
Metoprolol |
|
| NCI_Drug_Dictionary_ID |
694582 |
|
| PDQ_Closed_Trial_Search_ID |
694582 |
|
| PDQ_Open_Trial_Search_ID |
694582 |
|
| Preferred_Name |
Metoprolol |
|
| prefixIRI |
Thesaurus:C61845 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0025859 |
|
| subClassOf |