National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Mefloquine

Synonyms

MEFLOQUINE

Mefloquine

Definitions

A quinolinemethanol derivative with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the exact mechanism remains to be elucidated, mefloquine, a weak base, preferentially accumulates in lysosomes and disrupts lysosomal function and integrity, thereby leading to host cell death. Similar to chloroquine, the chemosensitizing and radiosensitizing activities of this agent may be related to its inhibition of autophagocytosis, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Compared to chloroquine, mefloquine has better blood-brain-barrier (BBB) penetration.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61827

CAS_Registry

53230-10-7

CHEBI_ID

CHEBI:63609

Chemical_Formula

C17H16F6N2O

code

C61827

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

A quinolinemethanol derivative with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the exact mechanism remains to be elucidated, mefloquine, a weak base, preferentially accumulates in lysosomes and disrupts lysosomal function and integrity, thereby leading to host cell death. Similar to chloroquine, the chemosensitizing and radiosensitizing activities of this agent may be related to its inhibition of autophagocytosis, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Compared to chloroquine, mefloquine has better blood-brain-barrier (BBB) penetration.

Display_Name

Mefloquine

FDA_UNII_Code

TML814419R

FULL_SYN

MEFLOQUINE

Mefloquine

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47600

label

Mefloquine

Legacy Concept Name

Mefloquine

NCI_Drug_Dictionary_ID

711805

PDQ_Closed_Trial_Search_ID

711805

PDQ_Open_Trial_Search_ID

711805

Preferred_Name

Mefloquine

prefixIRI

Thesaurus:C61827

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0025153

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C271

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/SNMI/C-56565 SNMI LOOM
http://purl.jp/bio/4/id/200906055274227490 IOBC LOOM
http://purl.obolibrary.org/obo/MESH_D015767 BERO LOOM
http://purl.bioontology.org/ontology/RXNORM/6694 RXNORM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0025153 OCHV LOOM
http://stirdf.jst.go.jp/id/200907060571233137 IOBC LOOM
http://purl.obolibrary.org/obo/IDOMAL_0000234 IDOMAL LOOM
http://purl.obolibrary.org/obo/SCDO_0000742 SCDO LOOM
http://purl.obolibrary.org/obo/CHEBI_63609 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_63609 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_63609 EUPATH LOOM
http://purl.obolibrary.org/obo/CHEBI_63609 INBANCIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_63609 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_63609 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_63609 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_63609 CIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_63609 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_63609 ODNAE LOOM
http://www.co-ode.org/ontologies/galen#Mefloquine GALEN LOOM
http://purl.obolibrary.org/obo/CHEBI_63681 FIDEO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015767 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#7879 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D015767 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387505001 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDDF/004873 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.810.410 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB00358 FTC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017920 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/VANDF/4019811 VANDF LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000711805 PDQ LOOM
http://purl.obolibrary.org/obo/NCIT_C61827 BERO LOOM
http://purl.obolibrary.org/obo/OMIT_0016413 OMIT LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147900 INBANCIDO LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147900 ODAE LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147900 CIDO LOOM
http://purl.bioontology.org/ontology/ATC/P01BC02 ATC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU013611 LOINC LOOM
https://go.drugbank.com/drugs/DB00358 MDM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147900 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/LP21305-5 LOINC LOOM