National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Isoxsuprine

Synonyms

ISOXSUPRINE

Isoxsuprine

Definitions

A benzyl alcohol derivative with vasodilator activity. The mechanism of action of isoxsuprine hydrochloride is controversial, because isoxsuprine has beta-adrenergic activities that could not be offset by beta-adrenergic blockers. Although stimulation of the beta adrenergic receptor increases blood flow to produce vasodilatation, this agent may also have direct effects on the contractility of smooth muscle. Additionally, isoxsuprine causes relaxation of uterine smooth muscle and may also produce positive inotropic and chronotropic effects on the myocardium.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61795

CAS_Registry

395-28-8

395-29-9

Chemical_Formula

C18H23NO3

code

C61795

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A benzyl alcohol derivative with vasodilator activity. The mechanism of action of isoxsuprine hydrochloride is controversial, because isoxsuprine has beta-adrenergic activities that could not be offset by beta-adrenergic blockers. Although stimulation of the beta adrenergic receptor increases blood flow to produce vasodilatation, this agent may also have direct effects on the contractility of smooth muscle. Additionally, isoxsuprine causes relaxation of uterine smooth muscle and may also produce positive inotropic and chronotropic effects on the myocardium.

FDA_UNII_Code

R15UI3245N

FULL_SYN

ISOXSUPRINE

Isoxsuprine

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47576

label

Isoxsuprine

Legacy Concept Name

Isoxsuprine

Preferred_Name

Isoxsuprine

prefixIRI

Thesaurus:C61795

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0022267

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48149

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29707

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http://stirdf.jst.go.jp/id/200907087936203360 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4019794 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.471.683.560 RH-MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C61795 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007556 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147883 NDFRT LOOM
http://purl.bioontology.org/ontology/RCD/x01RG RCD LOOM
http://purl.bioontology.org/ontology/MESH/D007556 MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/6066 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372818004 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906019775429088 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/004517 NDDF LOOM
http://www.gamuts.net/entity#isoxsuprine GAMUTS LOOM
https://go.drugbank.com/drugs/DB08941 MDM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6975 OCHV LOOM
http://purl.obolibrary.org/obo/OMIT_0008670 OMIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.100.624.427 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015662 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/ATC/C04AA01 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0022267 OCHV LOOM
http://purl.bioontology.org/ontology/SNMI/C-815A0 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.755.624.427 RH-MESH LOOM
http://purl.obolibrary.org/obo/MESH_D007556 BERO LOOM
http://scai.fraunhofer.de/AlzheimerOntology#isoxsuprine ADO LOOM
http://purl.obolibrary.org/obo/DRON_00013649 DRON LOOM