National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Gemifloxacin

Synonyms

Gemifloxacin

GEMIFLOXACIN

Definitions

A fluoroquinolone antibiotic with antimicrobial property. Gemifloxacin enters bacterial cells by diffusion through integral membrane porin pathway before targeting both DNA gyrase and topoisomerase IV, two enzymes critical for DNA replication and repair. This agent binds to the DNA/DNA-gyrase complex and inhibits the A subunits of the enzyme thereby preventing the bacterial chromosome from rejoining. This interferes with DNA replication and repair processes as well as transcription, and ultimately leads to bacterial cell death. Gemifloxacin targets at both Gram-positive, -negative and atypical human pathogens.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61775

CAS_Registry

175463-14-6

204519-64-2

CHEBI_ID

CHEBI:101853

Chemical_Formula

C18H20FN5O4

code

C61775

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A fluoroquinolone antibiotic with antimicrobial property. Gemifloxacin enters bacterial cells by diffusion through integral membrane porin pathway before targeting both DNA gyrase and topoisomerase IV, two enzymes critical for DNA replication and repair. This agent binds to the DNA/DNA-gyrase complex and inhibits the A subunits of the enzyme thereby preventing the bacterial chromosome from rejoining. This interferes with DNA replication and repair processes as well as transcription, and ultimately leads to bacterial cell death. Gemifloxacin targets at both Gram-positive, -negative and atypical human pathogens.

FDA_UNII_Code

OKR68Y0E4T

FULL_SYN

Gemifloxacin

GEMIFLOXACIN

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47548

label

Gemifloxacin

Legacy Concept Name

Gemifloxacin

Preferred_Name

Gemifloxacin

prefixIRI

Thesaurus:C61775

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0533545

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C795

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