National Cancer Institute Thesaurus

Last uploaded: March 26, 2019
Preferred Name

Fluvoxamine

Synonyms

Fluvoxamine

FLUVOXAMINE

fluvoxamine

Definitions

A 2-aminoethyl oxime ether of aralkylketones, with antidepressant, antiobsessive-compulsive, and anxiolytic properties. Fluvoxamine, chemically unrelated to other selective serotonin reuptake inhibitors, selectively blocks serotonin reuptake by inhibiting the serotonin reuptake pump at the presynaptic neuronal membrane. This increases serotonin levels within the synaptic cleft, prolongs serotonergic transmission and decreased serotonin turnover, thereby leading to antidepressant, anxiolytic and antiobsessive-compulsive effects. Fluvoxamine shows no significant affinity for histaminergic, alpha or beta adrenergic, muscarinic, or dopaminergic receptors in vitro.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61769

ALT_DEFINITION

A drug used to treat obsessive-compulsive disorder. It is a type of antidepressant agent and selective serotonin reuptake inhibitor (SSRI).

CAS_Registry

54739-18-3

CHEBI_ID

CHEBI:5138

Chemical_Formula

C15H21F3N2O2

code

C61769

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A 2-aminoethyl oxime ether of aralkylketones, with antidepressant, antiobsessive-compulsive, and anxiolytic properties. Fluvoxamine, chemically unrelated to other selective serotonin reuptake inhibitors, selectively blocks serotonin reuptake by inhibiting the serotonin reuptake pump at the presynaptic neuronal membrane. This increases serotonin levels within the synaptic cleft, prolongs serotonergic transmission and decreased serotonin turnover, thereby leading to antidepressant, anxiolytic and antiobsessive-compulsive effects. Fluvoxamine shows no significant affinity for histaminergic, alpha or beta adrenergic, muscarinic, or dopaminergic receptors in vitro.

FDA_UNII_Code

O4L1XPO44W

FULL_SYN

Fluvoxamine

FLUVOXAMINE

fluvoxamine

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29063

label

Fluvoxamine

Legacy_Concept_Name

Fluvoxamine

Preferred_Name

Fluvoxamine

prefixIRI

ncit:C61769

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0085228

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C94725

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C265

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http://scai.fraunhofer.de/AlzheimerOntology#fluvoxamine ADO LOOM
http://purl.jp/bio/4/id/200906011564757258 IOBC LOOM
http://purl.jp/bio/4/id/200906011564757258 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP14994-5 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/42355 RXNORM LOOM
http://purl.bioontology.org/ontology/CSP/5002-0034 CRISP LOOM
http://purl.bioontology.org/ontology/SNMI/C-62330 SNMI LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004137 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004137 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004137 DMTO LOOM
http://purl.bioontology.org/ontology/UATC/N06AB08 ATC LOOM
http://www.co-ode.org/ontologies/galen#Fluvoxamine GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.570.665.250 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5138 NIFSTD LOOM
http://purl.bioontology.org/ontology/NDDF/003633 NDDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372905008 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/96213009 SNOMEDCT LOOM
http://www.case.edu/EpSO.owl#Fluvoxamine EPSO LOOM
http://purl.bioontology.org/ontology/VANDF/4023976 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D016666 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D016666 MESH LOOM
http://www.drugbank.ca/drugs/DB00176 FTC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000021981 NDFRT LOOM
http://stirdf.jst.go.jp/id/200907098234918389 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002297 LOINC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Fluvoxamine APAONTO LOOM
http://purl.bioontology.org/ontology/RCD/x01As RCD LOOM