Preferred Name |
Fluvastatin |
|
Synonyms |
FLUVASTATIN Fluvastatin |
|
Definitions |
A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61768 |
|
CAS_Registry |
93957-54-1 |
|
CHEBI_ID |
CHEBI:38561 CHEBI:5136 |
|
Chemical_Formula |
C24H26FNO4 |
|
code |
C61768 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
Contributing_Source |
FDA GDC |
|
DEFINITION |
A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties. |
|
FDA_UNII_Code |
4L066368AS |
|
FULL_SYN |
FLUVASTATIN Fluvastatin |
|
Has_Salt_Form | ||
Is_Value_For_GDC_Property | ||
label |
Fluvastatin |
|
Legacy Concept Name |
Fluvastatin |
|
Maps_To |
Fluvastatin |
|
Preferred_Name |
Fluvastatin |
|
prefixIRI |
Thesaurus:C61768 |
|
Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C0082608 |
|
subClassOf |