National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Fluvastatin

Synonyms

FLUVASTATIN

Fluvastatin

Definitions

A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61768

CAS_Registry

93957-54-1

CHEBI_ID

CHEBI:38561

CHEBI:5136

Chemical_Formula

C24H26FNO4

code

C61768

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

FDA

GDC

DEFINITION

A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties.

FDA_UNII_Code

4L066368AS

FULL_SYN

FLUVASTATIN

Fluvastatin

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29062

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Fluvastatin

Legacy Concept Name

Fluvastatin

Maps_To

Fluvastatin

Preferred_Name

Fluvastatin

prefixIRI

Thesaurus:C61768

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0082608

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1655

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http://purl.obolibrary.org/obo/CHEBI_38561 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_38561 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_38561 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_38561 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_38561 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_38561 DIDEO LOOM
http://www.co-ode.org/ontologies/galen#Fluvastatin GALEN LOOM
http://purl.bioontology.org/ontology/RCD/x01R2 RCD LOOM
http://purl.obolibrary.org/obo/NCIT_C61768 BERO LOOM
http://purl.bioontology.org/ontology/RXNORM/41127 RXNORM LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025446 PMAPP-PMO LOOM
http://purl.jp/bio/4/id/200906068228431273 IOBC LOOM
http://stirdf.jst.go.jp/id/200907088307961169 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0082608 OCHV LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#15374 OCHV LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387585004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/MESH/D000077340 MESH LOOM
http://purl.obolibrary.org/obo/DRON_00012123 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_38562 BIOMODELS LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C065180 RH-MESH LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02123 MIO LOOM
https://go.drugbank.com/drugs/DB01095 MDM LOOM
http://purl.bioontology.org/ontology/LNC/LP171399-1 LOINC LOOM
http://www.drugbank.ca/drugs/DB01095 FTC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000021914 NDFRT LOOM
http://purl.bioontology.org/ontology/ATC/C10AA04 ATC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000021914 ODAE LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000021914 OCVDAE LOOM
http://purl.bioontology.org/ontology/VANDF/4023909 VANDF LOOM
http://scai.fraunhofer.de/AlzheimerOntology#fluvastatin ADO LOOM
http://purl.obolibrary.org/obo/HIO_0000304 HIO LOOM
http://purl.bioontology.org/ontology/SNMI/C-80830 SNMI LOOM