loading...| Preferred Name |
Ethambutol |
|
| Synonyms |
ETHAMBUTOL Ethambutol |
|
| Definitions |
An antibiotic with bacteriostatic, antimicrobial and antitubercular properties. Ethambutol interferes with the biosynthesis of arabinogalactan, a major polysaccharide of the mycobacterial cell wall. It inhibits the polymerization of cell wall arabinan of arabinogalactan and lipoarabinomannan by blocking arabinosyl transferases and induces the accumulation of D-arabinofuranosyl-P-decaprenol, an intermediate in arabinan biosynthesis. This results in halting bacterial growth. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61755 |
|
| CAS_Registry |
74-55-5 |
|
| CHEBI_ID |
CHEBI:4877 |
|
| Chemical_Formula |
C10H24N2O2 |
|
| code |
C61755 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
An antibiotic with bacteriostatic, antimicrobial and antitubercular properties. Ethambutol interferes with the biosynthesis of arabinogalactan, a major polysaccharide of the mycobacterial cell wall. It inhibits the polymerization of cell wall arabinan of arabinogalactan and lipoarabinomannan by blocking arabinosyl transferases and induces the accumulation of D-arabinofuranosyl-P-decaprenol, an intermediate in arabinan biosynthesis. This results in halting bacterial growth. |
|
| FDA_UNII_Code |
8G167061QZ |
|
| FULL_SYN |
ETHAMBUTOL Ethambutol |
|
| Has_Salt_Form | ||
| label |
Ethambutol |
|
| Legacy Concept Name |
Ethambutol |
|
| NCI_Drug_Dictionary_ID |
701810 |
|
| PDQ_Closed_Trial_Search_ID |
701810 |
|
| PDQ_Open_Trial_Search_ID |
701810 |
|
| Preferred_Name |
Ethambutol |
|
| prefixIRI |
Thesaurus:C61755 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0014964 |
|
| subClassOf |