loading...| Preferred Name |
Escitalopram |
|
| Synonyms |
escitalopram ESCITALOPRAM S(+)-Citalopram (S)-Citalopram Escitalopram Seroplex |
|
| Definitions |
The active S-stereoisomer of the selective serotonin reuptake inhibitor (SSRI) citalopram with antidepressant, anti-obsessive-compulsive and antibulimic properties. Escitalopram inhibits the reuptake of the neurotransmitter serotonin (5-HT) at the serotonin reuptake pump of the neuronal membrane of the presynaptic cell, thereby increasing levels of 5-HT within the synaptic cleft and enhancing the actions of serotonin on 5HT1A autoreceptors. Unlike other SSRIs, escitalopram appears to not only bind to a primary high-affinity site on the serotonin transporter protein but also to a secondary lower-affinity allosteric site that is considered to stabilize and prolong drug binding. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61754 |
|
| ALT_DEFINITION |
A drug used to treat depression and certain anxiety disorders. It belongs to the family of drugs called selective serotonin reuptake inhibitors (SSRIs). |
|
| CAS_Registry |
128196-01-0 |
|
| CHEBI_ID |
CHEBI:36791 |
|
| Chemical_Formula |
C20H21FN2O |
|
| code |
C61754 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
The active S-stereoisomer of the selective serotonin reuptake inhibitor (SSRI) citalopram with antidepressant, anti-obsessive-compulsive and antibulimic properties. Escitalopram inhibits the reuptake of the neurotransmitter serotonin (5-HT) at the serotonin reuptake pump of the neuronal membrane of the presynaptic cell, thereby increasing levels of 5-HT within the synaptic cleft and enhancing the actions of serotonin on 5HT1A autoreceptors. Unlike other SSRIs, escitalopram appears to not only bind to a primary high-affinity site on the serotonin transporter protein but also to a secondary lower-affinity allosteric site that is considered to stabilize and prolong drug binding. |
|
| Display_Name |
Escitalopram |
|
| FDA_UNII_Code |
4O4S742ANY |
|
| FULL_SYN |
escitalopram ESCITALOPRAM S(+)-Citalopram (S)-Citalopram Escitalopram Seroplex |
|
| Has_Salt_Form | ||
| Has_Target | ||
| label |
Escitalopram |
|
| Legacy Concept Name |
Escitalopram |
|
| Preferred_Name |
Escitalopram |
|
| prefixIRI |
Thesaurus:C61754 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1099456 |
|
| subClassOf |