loading...| Preferred Name |
Ertapenem |
|
| Synonyms |
ERTAPENEM Ertapenem |
|
| Definitions |
A 1-beta-methyl carbapenem and broad-spectrum beta-lactam antibiotic with bactericidal property. Ertapenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, in particular PBPs 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Inhibition results in a weakening and subsequent lysis of the cell wall leading to cell death of Gram-positive and Gram-negative aerobic and anaerobic pathogens. This agent is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, cephalosporinases and extended-spectrum beta-lactamases. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61752 |
|
| CAS_Registry |
153832-46-3 |
|
| CHEBI_ID |
CHEBI:404903 |
|
| Chemical_Formula |
C22H25N3O7S |
|
| code |
C61752 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A 1-beta-methyl carbapenem and broad-spectrum beta-lactam antibiotic with bactericidal property. Ertapenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, in particular PBPs 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Inhibition results in a weakening and subsequent lysis of the cell wall leading to cell death of Gram-positive and Gram-negative aerobic and anaerobic pathogens. This agent is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, cephalosporinases and extended-spectrum beta-lactamases. |
|
| FDA_UNII_Code |
G32F6EID2H |
|
| FULL_SYN |
ERTAPENEM Ertapenem |
|
| Has_Salt_Form | ||
| label |
Ertapenem |
|
| Legacy Concept Name |
Ertapenem |
|
| Preferred_Name |
Ertapenem |
|
| prefixIRI |
Thesaurus:C61752 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1120106 |
|
| subClassOf |