National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Ertapenem

Synonyms

Ertapenem

ERTAPENEM

Definitions

A 1-beta-methyl carbapenem and broad-spectrum beta-lactam antibiotic with bactericidal property. Ertapenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, in particular PBPs 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Inhibition results in a weakening and subsequent lysis of the cell wall leading to cell death of Gram-positive and Gram-negative aerobic and anaerobic pathogens. This agent is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, cephalosporinases and extended-spectrum beta-lactamases.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61752

CAS_Registry

153832-46-3

CHEBI_ID

CHEBI:404903

Chemical_Formula

C22H25N3O7S

code

C61752

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A 1-beta-methyl carbapenem and broad-spectrum beta-lactam antibiotic with bactericidal property. Ertapenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, in particular PBPs 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Inhibition results in a weakening and subsequent lysis of the cell wall leading to cell death of Gram-positive and Gram-negative aerobic and anaerobic pathogens. This agent is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, cephalosporinases and extended-spectrum beta-lactamases.

FDA_UNII_Code

G32F6EID2H

FULL_SYN

Ertapenem

ERTAPENEM

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61753

label

Ertapenem

Legacy_Concept_Name

Ertapenem

Preferred_Name

Ertapenem

prefixIRI

ncit:C61752

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1120106

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C260

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http://purl.obolibrary.org/obo/DRON_00018560 DRON LOOM
http://purl.bioontology.org/ontology/UATC/J01DH03 ATC LOOM
http://purl.bioontology.org/ontology/NDDF/009554 NDDF LOOM
http://purl.obolibrary.org/obo/CHEBI_404903 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_404903 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_404903 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_404903 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_404903 GENEPIO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C446479 RH-MESH LOOM
http://purl.obolibrary.org/obo/ARO_0000070 ARO LOOM
http://www.co-ode.org/ontologies/galen#Ertapenem GALEN LOOM
http://purl.bioontology.org/ontology/LNC/LP33356-4 LOINC LOOM
http://purl.bioontology.org/ontology/VANDF/4021283 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148720 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/396346003 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C1120106 OCHV LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#54784 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D000077727 MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU016193 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/325642 RXNORM LOOM