Ergotamine

ERGOTAMINE

Ergotamine

A naturally occurring ergot alkaloid with vasoconstrictor and analgesic property. Ergotamine selectively binds and activates serotonin (5-HT) 1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, thereby resulting in vasoconstriction and reducing the blood flow in cerebral arteries that may lead to relieve of vascular headaches. This agent also selectively binds to alpha-adrenergic receptors, thereby stimulating vascular smooth muscle and causing vasoconstriction in both arteries and veins, which also contributes to the relief of headaches. Furthermore, the activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61751

113-15-5

CHEBI:64318

C33H35N5O5

C61751

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

FDA

A naturally occurring ergot alkaloid with vasoconstrictor and analgesic property. Ergotamine selectively binds and activates serotonin (5-HT) 1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, thereby resulting in vasoconstriction and reducing the blood flow in cerebral arteries that may lead to relieve of vascular headaches. This agent also selectively binds to alpha-adrenergic receptors, thereby stimulating vascular smooth muscle and causing vasoconstriction in both arteries and veins, which also contributes to the relief of headaches. Furthermore, the activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.

PR834Q503T

ERGOTAMINE

Ergotamine

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47517

Ergotamine

Ergotamine

Ergotamine

Thesaurus:C61751

Pharmacologic Substance

C0014710

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47794