Doxylamine

DOXYLAMINE

Doxylamine

A first generation ethanolamine with antiinflammatory, sedative and antihistamine properties. Doxylamine competitively inhibits the histamine 1 (H1) receptor, thereby preventing the action of endogenous histamine as well as the subsequent release of pro-inflammatory mediators from basophils and mast cells. This agent acts as an inverse agonist that combines with, and stabilizes the inactive form of the H1-receptor, shifting the H1 receptor equilibrium toward the inactive state. This results in downregulation of nuclear factor-kappaB (NF-kappaB) and NF-kappaB dependent antigen presentation, chemotaxis, as well as expression of cell-adhesion molecules and pro-inflammatory cytokines.

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61738

469-21-6

CHEBI:51380

C17H22N2O

C61738

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

FDA

A first generation ethanolamine with antiinflammatory, sedative and antihistamine properties. Doxylamine competitively inhibits the histamine 1 (H1) receptor, thereby preventing the action of endogenous histamine as well as the subsequent release of pro-inflammatory mediators from basophils and mast cells. This agent acts as an inverse agonist that combines with, and stabilizes the inactive form of the H1-receptor, shifting the H1 receptor equilibrium toward the inactive state. This results in downregulation of nuclear factor-kappaB (NF-kappaB) and NF-kappaB dependent antigen presentation, chemotaxis, as well as expression of cell-adhesion molecules and pro-inflammatory cytokines.

95QB77JKPL

DOXYLAMINE

Doxylamine

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47501

Doxylamine

Doxylamine

Doxylamine

Thesaurus:C61738

Pharmacologic Substance

C0013092

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29578