National Cancer Institute Thesaurus

Last uploaded: May 28, 2019
Preferred Name

Docetaxel Anhydrous

Synonyms

Docetaxel Anhydrous

DOCEFREZ

DOCETAXEL ANHYDROUS

Definitions

The anhydrous form of docetaxel, a semisynthetic side-chain analogue of paclitaxel with antineoplastic property. Docetaxel binds specifically to the beta-tubulin subunit of microtubules and thereby antagonizes the disassembly of the microtubule proteins. This results in the persistence of aberrant microtubule structures and results in cell-cycle arrest and subsequent cell death.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61734

CAS_Registry

114977-28-5

CHEBI_ID

CHEBI:4672

Chemical_Formula

C43H53NO14

code

C61734

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

Contributing_Source

FDA

DEFINITION

The anhydrous form of docetaxel, a semisynthetic side-chain analogue of paclitaxel with antineoplastic property. Docetaxel binds specifically to the beta-tubulin subunit of microtubules and thereby antagonizes the disassembly of the microtubule proteins. This results in the persistence of aberrant microtubule structures and results in cell-cycle arrest and subsequent cell death.

FDA_UNII_Code

699121PHCA

FULL_SYN

Docetaxel Anhydrous

DOCEFREZ

DOCETAXEL ANHYDROUS

label

Docetaxel Anhydrous

Legacy_Concept_Name

Docetaxel_Anhydrous

Preferred_Name

Docetaxel Anhydrous

prefixIRI

ncit:C61734

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0771375

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67437

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1490

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http://purl.obolibrary.org/obo/CHEBI_4672 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_4672 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4672 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4672 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_4672 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_4672 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_4672 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_4672 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_4672 CHEBI LOOM
http://purl.bioontology.org/ontology/RXNORM/1299922 RXNORM LOOM
http://purl.bioontology.org/ontology/NDDF/005188 NDDF LOOM