National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Disopyramide

Synonyms

DISOPYRAMIDE

Disopyramide

Definitions

A class IA anti-arrhythmic agent with cardiac depressant property. Disopyramide blocks the fast sodium channel in normal cardiac cell membranes within atrial and ventricular tissues. This slows the rate and amplitude of phase 0 depolarization and thus prolongs the duration of the action potential, thereby reducing cell excitability and conduction velocity. Further, disopyramide directly decreases the rate of diastolic (phase 4) depolarization in cells with normal or augmented automaticity. Disopyramide also blocks potassium channel and results in prolonged QT interval, thus increases the effective refractory period. This agent also possesses anticholinergic property.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61730

CAS_Registry

3737-09-5

CHEBI_ID

CHEBI:4657

Chemical_Formula

C21H29N3O

code

C61730

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A class IA anti-arrhythmic agent with cardiac depressant property. Disopyramide blocks the fast sodium channel in normal cardiac cell membranes within atrial and ventricular tissues. This slows the rate and amplitude of phase 0 depolarization and thus prolongs the duration of the action potential, thereby reducing cell excitability and conduction velocity. Further, disopyramide directly decreases the rate of diastolic (phase 4) depolarization in cells with normal or augmented automaticity. Disopyramide also blocks potassium channel and results in prolonged QT interval, thus increases the effective refractory period. This agent also possesses anticholinergic property.

FDA_UNII_Code

GFO928U8MQ

FULL_SYN

DISOPYRAMIDE

Disopyramide

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47497

label

Disopyramide

Legacy_Concept_Name

Disopyramide

Preferred_Name

Disopyramide

prefixIRI

ncit:C61730

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0012702

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47793

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C93038

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http://purl.bioontology.org/ontology/VANDF/4019729 VANDF LOOM
http://purl.bioontology.org/ontology/UATC/C01BA03 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/3541 RXNORM LOOM
http://bmi.utah.edu/ontologies/hfontology/C0012702 HFO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004206 RH-MESH LOOM
http://data.bnf.fr/ark:/12148/cb12309819r FAST-TOPICAL LOOM
http://stirdf.jst.go.jp/id/200907024566670506 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003353 LOINC LOOM
http://purl.bioontology.org/ontology/CSP/2509-4924 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.725.227 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Disopyramide GALEN LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006058 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006058 DMTO LOOM
http://purl.bioontology.org/ontology/LNC/LP16118-9 LOINC LOOM
http://purl.bioontology.org/ontology/MESH/D004206 MESH LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006055 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006055 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006055 DMTO LOOM
http://purl.bioontology.org/ontology/SNMI/C-803B0 SNMI LOOM
http://purl.obolibrary.org/obo/CHEBI_4657 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_4657 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4657 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_4657 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_4657 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_4657 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_4657 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_4657 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4657 NIFSTD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#4025 OCHV LOOM
http://purl.bioontology.org/ontology/NDDF/000623 NDDF LOOM
http://purl.jp/bio/4/id/200906050373628453 IOBC LOOM
http://www.drugbank.ca/drugs/DB00280 FTC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147821 OCVDAE LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372844004 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0012702 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147821 NDFRT LOOM