National Cancer Institute Thesaurus

Last uploaded: October 30, 2018
Preferred Name

Limonene, (+/-)-

Synonyms

Eulimen

Cinene

1-methyl-4-(1-methylethenyl)cyclohexene

(+/-)-1-methyl-4-(1-methylethenyl)cyclohexene

Dipentene

DL-Limonene

Nesol

Limonene, (+/-)-

LIMONENE, (+/-)-

1-methyl-4-prop-1-en-2-yl-cyclohexene

Cajeputene

Limonene

Definitions

A racemic mixture of limonene, a natural cyclic monoterpene and major component of the oil extracted from citrus rind with chemo-preventive and antitumor activities. The metabolites of DL-limonene, perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol are suggested to inhibit tumor growth through inhibition of p21-dependent signaling, induce apoptosis via the induction of the transforming growth factor beta-signaling pathway, inhibit post-translational modification of signal transduction proteins, result in G1 cell cycle arrest as well as cause differential expression of cell cycle- and apoptosis-related genes.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61709

CAS_Registry

138-86-3

CHEBI_ID

CHEBI:15384

Chemical_Formula

C10H16

code

C61709

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

Contributing_Source

FDA

DEFINITION

A racemic mixture of limonene, a natural cyclic monoterpene and major component of the oil extracted from citrus rind with chemo-preventive and antitumor activities. The metabolites of DL-limonene, perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol are suggested to inhibit tumor growth through inhibition of p21-dependent signaling, induce apoptosis via the induction of the transforming growth factor beta-signaling pathway, inhibit post-translational modification of signal transduction proteins, result in G1 cell cycle arrest as well as cause differential expression of cell cycle- and apoptosis-related genes.

FDA_UNII_Code

9MC3I34447

FULL_SYN

Eulimen

Cinene

1-methyl-4-(1-methylethenyl)cyclohexene

(+/-)-1-methyl-4-(1-methylethenyl)cyclohexene

Dipentene

DL-Limonene

Nesol

Limonene, (+/-)-

LIMONENE, (+/-)-

1-methyl-4-prop-1-en-2-yl-cyclohexene

Cajeputene

Limonene

label

Limonene, (+/-)-

Legacy_Concept_Name

DL-Limonene

NSC_Code

844

21446

Preferred_Name

Limonene, (+/-)-

prefixIRI

ncit:C61709

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1880232

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C68542

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http://purl.obolibrary.org/obo/CHEBI_15384 go-plus LOOM
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http://purl.obolibrary.org/obo/CHEBI_15384 Neuro Behavior Ontology LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 Chemical Entities of Biological Interest Ontology LOOM
http://purl.bioontology.org/ontology/SNMI/C-31149 Systematized Nomenclature of Medicine, International Version LOOM
http://purl.bioontology.org/ontology/RXNORM/1426777 RxNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C008281 Robert Hoehndorf Version of MeSH LOOM
http://purl.obolibrary.org/obo/SIBO_0000223 Social Inset Behavior Ontology LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/11038000 SNOMED CT LOOM
http://purl.jp/bio/4/id/200906090981614033 Interlinking Ontology for Biological Concepts LOOM
http://purl.bioontology.org/ontology/RXNORM/28730 RxNORM LOOM
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http://purl.bioontology.org/ontology/RCD/X79EZ Read Codes, Clinical Terms Version 3 (CTV3) LOOM
http://purl.bioontology.org/ontology/NDDF/007167 National Drug Data File LOOM
http://purl.jp/bio/4/id/200906023325459561 Interlinking Ontology for Biological Concepts LOOM
http://purl.bioontology.org/ontology/MESH/C008281 Medical Subject Headings LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/411238006 SNOMED CT LOOM
http://purl.obolibrary.org/obo/SIBO_0000359 Social Inset Behavior Ontology LOOM
http://purl.obolibrary.org/obo/DRON_00015179 The Drug Ontology LOOM
http://purl.bioontology.org/ontology/RXNORM/1363991 RxNORM LOOM