Preferred Name |
Limonene, (+/-)- |
|
Synonyms |
Limonene, (+/-)- DL-Limonene (+/-)-1-methyl-4-(1-methylethenyl)cyclohexene 1-methyl-4-(1-methylethenyl)cyclohexene LIMONENE, (+/-)- 1-methyl-4-prop-1-en-2-yl-cyclohexene Cajeputene Cinene Dipentene Eulimen Limonene Nesol |
|
Definitions |
A racemic mixture of limonene, a natural cyclic monoterpene and major component of the oil extracted from citrus rind with chemo-preventive and antitumor activities. The metabolites of DL-limonene, perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol are suggested to inhibit tumor growth through inhibition of p21-dependent signaling, induce apoptosis via the induction of the transforming growth factor beta-signaling pathway, inhibit post-translational modification of signal transduction proteins, result in G1 cell cycle arrest as well as cause differential expression of cell cycle- and apoptosis-related genes. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61709 |
|
CAS_Registry |
138-86-3 |
|
CHEBI_ID |
CHEBI:15384 |
|
Chemical_Formula |
C10H16 |
|
code |
C61709 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
Contributing_Source |
FDA GDC |
|
DEFINITION |
A racemic mixture of limonene, a natural cyclic monoterpene and major component of the oil extracted from citrus rind with chemo-preventive and antitumor activities. The metabolites of DL-limonene, perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol are suggested to inhibit tumor growth through inhibition of p21-dependent signaling, induce apoptosis via the induction of the transforming growth factor beta-signaling pathway, inhibit post-translational modification of signal transduction proteins, result in G1 cell cycle arrest as well as cause differential expression of cell cycle- and apoptosis-related genes. |
|
FDA_UNII_Code |
9MC3I34447 |
|
FULL_SYN |
Limonene, (+/-)- DL-Limonene (+/-)-1-methyl-4-(1-methylethenyl)cyclohexene 1-methyl-4-(1-methylethenyl)cyclohexene LIMONENE, (+/-)- 1-methyl-4-prop-1-en-2-yl-cyclohexene Cajeputene Cinene Dipentene Eulimen Limonene Nesol |
|
Is_Value_For_GDC_Property | ||
label |
Limonene, (+/-)- |
|
Legacy Concept Name |
DL-Limonene |
|
Maps_To |
Limonene, (+/-)- |
|
NSC Number |
21446 844 |
|
Preferred_Name |
Limonene, (+/-)- |
|
prefixIRI |
Thesaurus:C61709 |
|
Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C1880232 |
|
subClassOf |