National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Limonene, (+/-)-

Synonyms

Limonene, (+/-)-

DL-Limonene

(+/-)-1-methyl-4-(1-methylethenyl)cyclohexene

1-methyl-4-(1-methylethenyl)cyclohexene

LIMONENE, (+/-)-

1-methyl-4-prop-1-en-2-yl-cyclohexene

Cajeputene

Cinene

Dipentene

Eulimen

Limonene

Nesol

Definitions

A racemic mixture of limonene, a natural cyclic monoterpene and major component of the oil extracted from citrus rind with chemo-preventive and antitumor activities. The metabolites of DL-limonene, perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol are suggested to inhibit tumor growth through inhibition of p21-dependent signaling, induce apoptosis via the induction of the transforming growth factor beta-signaling pathway, inhibit post-translational modification of signal transduction proteins, result in G1 cell cycle arrest as well as cause differential expression of cell cycle- and apoptosis-related genes.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61709

CAS_Registry

138-86-3

CHEBI_ID

CHEBI:15384

Chemical_Formula

C10H16

code

C61709

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

FDA

GDC

DEFINITION

A racemic mixture of limonene, a natural cyclic monoterpene and major component of the oil extracted from citrus rind with chemo-preventive and antitumor activities. The metabolites of DL-limonene, perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol are suggested to inhibit tumor growth through inhibition of p21-dependent signaling, induce apoptosis via the induction of the transforming growth factor beta-signaling pathway, inhibit post-translational modification of signal transduction proteins, result in G1 cell cycle arrest as well as cause differential expression of cell cycle- and apoptosis-related genes.

FDA_UNII_Code

9MC3I34447

FULL_SYN

Limonene, (+/-)-

DL-Limonene

(+/-)-1-methyl-4-(1-methylethenyl)cyclohexene

1-methyl-4-(1-methylethenyl)cyclohexene

LIMONENE, (+/-)-

1-methyl-4-prop-1-en-2-yl-cyclohexene

Cajeputene

Cinene

Dipentene

Eulimen

Limonene

Nesol

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Limonene, (+/-)-

Legacy Concept Name

DL-Limonene

Maps_To

Limonene, (+/-)-

NSC Number

21446

844

Preferred_Name

Limonene, (+/-)-

prefixIRI

Thesaurus:C61709

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1880232

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C68542

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http://purl.obolibrary.org/obo/CHEBI_15384 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 OCMR LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_15384 GO-PLUS LOOM
http://purl.bioontology.org/ontology/RXNORM/1426477 RXNORM LOOM
http://purl.bioontology.org/ontology/RXNORM/1426476 RXNORM LOOM
http://stirdf.jst.go.jp/id/200907010163633715 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-31149 SNMI LOOM
http://purl.bioontology.org/ontology/MESH/D000077222 MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/1426777 RXNORM LOOM
http://purl.obolibrary.org/obo/NCIT_C61714 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/11038000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RCD/X79EZ RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C008281 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14289 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/28730 RXNORM LOOM
http://purl.jp/bio/4/id/200906023325459561 IOBC LOOM
http://purl.obolibrary.org/obo/NCIT_C61709 BERO LOOM
http://purl.obolibrary.org/obo/UPa_UPC06078 UPA LOOM
http://purl.bioontology.org/ontology/RXNORM/1363991 RXNORM LOOM
http://purl.jp/bio/4/id/200906090981614033 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/007167 NDDF LOOM
http://purl.obolibrary.org/obo/SIBO_0000359 SIBO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000664042 PDQ LOOM
http://stirdf.jst.go.jp/id/200907004949773006 IOBC LOOM
http://purl.obolibrary.org/obo/SIBO_0000223 SIBO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0064992 OCHV LOOM