National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Desmopressin

Synonyms

DESMOPRESSIN

1-Deamino-8-D-arginine Vasopressin

Desmopressin

Definitions

A synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. Desmopressin binds to V2 receptors in renal collecting ducts which leads to exocytosis of von Willebrand factor (VWF) and tissue plasminogen activator (t-PA) from Weibel-Palade bodies, thereby increasing water resorption. This agent also increases nitric oxide (NO) production via activation of endothelial NO synthase, thereby induces afferent arteriolar vasodilation. Furthermore, desmopressin stimulates the release of factor VIII from endothelial cells mediated through V1a receptor, thereby promotes blood coagulation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61701

CAS_Registry

16679-58-6

CHEBI_ID

CHEBI:4450

Chemical_Formula

C46H64N14O12S2

code

C61701

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. Desmopressin binds to V2 receptors in renal collecting ducts which leads to exocytosis of von Willebrand factor (VWF) and tissue plasminogen activator (t-PA) from Weibel-Palade bodies, thereby increasing water resorption. This agent also increases nitric oxide (NO) production via activation of endothelial NO synthase, thereby induces afferent arteriolar vasodilation. Furthermore, desmopressin stimulates the release of factor VIII from endothelial cells mediated through V1a receptor, thereby promotes blood coagulation.

FDA_UNII_Code

ENR1LLB0FP

FULL_SYN

DESMOPRESSIN

1-Deamino-8-D-arginine Vasopressin

Desmopressin

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47475

label

Desmopressin

Legacy_Concept_Name

Desmopressin

Preferred_Name

Desmopressin

prefixIRI

ncit:C61701

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0011701

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80212

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