Preferred Name |
Deserpidine |
|
Synonyms |
Deserpidine DESERPIDINE Harmonyl |
|
Definitions |
An ester alkaloid derived from Rauwolfia canescens with antihypertensive activity. Deserpidine is a competitive inhibitor of the angiotensin converting enzyme (ACE). By competing with angiotensin I for ACE, deserpidine blocks the conversion of angiotensin I to angiotensin II, which is a potent vasoconstrictor. Reduced level of serum angiotensin II causes a decrease in blood pressure. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61699 |
|
CAS_Registry |
131-01-1 |
|
CHEBI_ID |
CHEBI:27478 |
|
Chemical_Formula |
C32H38N2O8 |
|
code |
C61699 |
|
Concept_In_Subset | ||
Contributing_Source |
FDA |
|
DEFINITION |
An ester alkaloid derived from Rauwolfia canescens with antihypertensive activity. Deserpidine is a competitive inhibitor of the angiotensin converting enzyme (ACE). By competing with angiotensin I for ACE, deserpidine blocks the conversion of angiotensin I to angiotensin II, which is a potent vasoconstrictor. Reduced level of serum angiotensin II causes a decrease in blood pressure. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex. |
|
FDA_UNII_Code |
9016E3VB47 |
|
FULL_SYN |
Deserpidine DESERPIDINE Harmonyl |
|
label |
Deserpidine |
|
Legacy Concept Name |
Deserpidine |
|
Preferred_Name |
Deserpidine |
|
prefixIRI |
Thesaurus:C61699 |
|
Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C0175158 |
|
subClassOf |