National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Deserpidine

Synonyms

Deserpidine

DESERPIDINE

Harmonyl

Definitions

An ester alkaloid derived from Rauwolfia canescens with antihypertensive activity. Deserpidine is a competitive inhibitor of the angiotensin converting enzyme (ACE). By competing with angiotensin I for ACE, deserpidine blocks the conversion of angiotensin I to angiotensin II, which is a potent vasoconstrictor. Reduced level of serum angiotensin II causes a decrease in blood pressure. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61699

CAS_Registry

131-01-1

CHEBI_ID

CHEBI:27478

Chemical_Formula

C32H38N2O8

code

C61699

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

An ester alkaloid derived from Rauwolfia canescens with antihypertensive activity. Deserpidine is a competitive inhibitor of the angiotensin converting enzyme (ACE). By competing with angiotensin I for ACE, deserpidine blocks the conversion of angiotensin I to angiotensin II, which is a potent vasoconstrictor. Reduced level of serum angiotensin II causes a decrease in blood pressure. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex.

FDA_UNII_Code

9016E3VB47

FULL_SYN

Deserpidine

DESERPIDINE

Harmonyl

label

Deserpidine

Legacy Concept Name

Deserpidine

Preferred_Name

Deserpidine

prefixIRI

Thesaurus:C61699

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0175158

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C270

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