National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Ciclopirox

Synonyms

CICLOPIROX

Ciclopirox

Definitions

A synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. Ciclopirox exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. This may lead to a loss of activity of enzymes that are essential for cellular metabolism, organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61677

CAS_Registry

29342-05-0

CHEBI_ID

CHEBI:453011

Chemical_Formula

C12H17NO2

code

C61677

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. Ciclopirox exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. This may lead to a loss of activity of enzymes that are essential for cellular metabolism, organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).

FDA_UNII_Code

19W019ZDRJ

FULL_SYN

CICLOPIROX

Ciclopirox

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65327

label

Ciclopirox

Legacy Concept Name

Ciclopirox

Preferred_Name

Ciclopirox

prefixIRI

Thesaurus:C61677

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0055711

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C514

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