National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Ceftizoxime

Synonyms

CEFTIZOXIME

Ceftizoxime

Definitions

A semisynthetic, broad-spectrum, beta-lactamase-resistant, third-generation cephalosporin with antibacterial activity. Ceftizoxime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61668

CAS_Registry

68401-81-0

CHEBI_ID

CHEBI:553473

Chemical_Formula

C13H13N5O5S2

code

C61668

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A semisynthetic, broad-spectrum, beta-lactamase-resistant, third-generation cephalosporin with antibacterial activity. Ceftizoxime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

FDA_UNII_Code

C43C467DPE

FULL_SYN

CEFTIZOXIME

Ceftizoxime

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47438

label

Ceftizoxime

Legacy Concept Name

Ceftixomine

Preferred_Name

Ceftizoxime

prefixIRI

Thesaurus:C61668

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0007560

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357

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Delete Mapping To Ontology Source
http://sbmi.uth.tmc.edu/ontology/ochv#2570 OCHV LOOM
https://go.drugbank.com/drugs/DB01332 MDM LOOM
http://purl.obolibrary.org/obo/CHEBI_553473 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_553473 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_553473 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_553473 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_553473 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_553473 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_553473 GENEPIO LOOM
http://purl.bioontology.org/ontology/SNMI/C-53550 SNMI LOOM
http://purl.obolibrary.org/obo/ARO_3004007 ARO LOOM
http://stirdf.jst.go.jp/id/200907090347655251 IOBC LOOM
http://purl.jp/bio/4/id/200906023687567885 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/004847 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.249.190.190.145 RH-MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0016081 OMIT LOOM
http://purl.bioontology.org/ontology/VANDF/4019666 VANDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0007560 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D015296 MESH LOOM
http://purl.bioontology.org/ontology/ATC/J01DD07 ATC LOOM
http://www.co-ode.org/ontologies/galen#Ceftizoxime GALEN LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015889 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372770006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/2192 RXNORM LOOM
http://purl.bioontology.org/ontology/RCD/e67.. RCD LOOM
http://purl.bioontology.org/ontology/LNC/LP15253-5 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015296 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.249.190.190.145 RH-MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C61668 BERO LOOM
http://purl.obolibrary.org/obo/MESH_D015296 BERO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004181 LOINC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147758 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.665.074.190.190.145 RH-MESH LOOM