National Cancer Institute Thesaurus

Last uploaded: August 27, 2019
Preferred Name

Cefoperazone

Synonyms

Cefoperazone

CEFOPERAZONE

Definitions

A semisynthetic, broad-spectrum, third-generation cephalosporin with antibacterial activity. Cefoperazone binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61663

CAS_Registry

62893-19-0

CHEBI_ID

CHEBI:3493

Chemical_Formula

C25H27N9O8S2

code

C61663

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A semisynthetic, broad-spectrum, third-generation cephalosporin with antibacterial activity. Cefoperazone binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

FDA_UNII_Code

7U75I1278D

FULL_SYN

Cefoperazone

CEFOPERAZONE

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47435

label

Cefoperazone

Legacy_Concept_Name

Cefoperazone

Preferred_Name

Cefoperazone

prefixIRI

ncit:C61663

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0007552

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357

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http://purl.bioontology.org/ontology/RXNORM/2184 RXNORM LOOM
http://purl.bioontology.org/ontology/VANDF/4019662 VANDF LOOM
http://purl.bioontology.org/ontology/SNMI/C-53520 SNMI LOOM
http://purl.jp/bio/4/id/200906013937981512 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/004846 NDDF LOOM
http://purl.bioontology.org/ontology/UATC/J01DD12 ATC LOOM
http://purl.obolibrary.org/obo/DRON_00012879 DRON LOOM
http://purl.bioontology.org/ontology/LNC/MTHU001214 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.249.150.160 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.665.074.150.160 RH-MESH LOOM
http://id.loc.gov/authorities/subjects/sh89005967 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372743004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147754 NDFRT LOOM
http://purl.obolibrary.org/obo/ARO_3004003 ARO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002438 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.249.150.160 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_3493 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3493 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3493 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_3493 GENEPIO LOOM
http://purl.bioontology.org/ontology/MESH/D002438 MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP14524-0 LOINC LOOM
http://stirdf.jst.go.jp/id/200907056171478516 IOBC LOOM