National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Bromodiphenhydramine

Synonyms

Bromodiphenhydramine

Ethanamine, 2-((4-bromophenyl)phenylmethoxy)-n,n-dimethyl-

BROMODIPHENHYDRAMINE

Bromazine

Definitions

A brominated derivative of diphenhydramine, an ethanolamine derivative and histamine H1 receptor antagonist with anti-allergic, sedative, antiemetic and anticholinergic properties. Bromazine competitively and selectively blocks central and peripheral histamine H1 receptors, thereby alleviating the symptoms caused by endogenous histamine on bronchial, capillary and gastrointestinal (GI) smooth muscles. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, itching, and spasmodic contractions of GI smooth muscle. In addition, bromazine binds to and blocks peripheral and central muscarinic receptors.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61654

CAS_Registry

118-23-0

CHEBI_ID

CHEBI:59177

Chemical_Formula

C17H20BrNO

code

C61654

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A brominated derivative of diphenhydramine, an ethanolamine derivative and histamine H1 receptor antagonist with anti-allergic, sedative, antiemetic and anticholinergic properties. Bromazine competitively and selectively blocks central and peripheral histamine H1 receptors, thereby alleviating the symptoms caused by endogenous histamine on bronchial, capillary and gastrointestinal (GI) smooth muscles. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, itching, and spasmodic contractions of GI smooth muscle. In addition, bromazine binds to and blocks peripheral and central muscarinic receptors.

FDA_UNII_Code

T032BI7727

FULL_SYN

Bromodiphenhydramine

Ethanamine, 2-((4-bromophenyl)phenylmethoxy)-n,n-dimethyl-

BROMODIPHENHYDRAMINE

Bromazine

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47421

label

Bromodiphenhydramine

Legacy Concept Name

Bromodiphenhydramine

Preferred_Name

Bromodiphenhydramine

prefixIRI

Thesaurus:C61654

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0054120

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29578

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