National Cancer Institute Thesaurus

Last uploaded: February 4, 2019
Preferred Name

Amiloride

Synonyms

AMILORIDE

Amiloride

Definitions

A synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels located in the distal tubules and collecting ducts of the kidney, thereby preventing the absorption of sodium and increasing its excretion along with water, to produce naturesis. In response to the hypernatremic conditions in the kidney, the plasma membrane becomes hyperpolarized and electrochemical forces are reduced, which then prevents the excretion of potassium and hydrogen into the lumen.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61633

CAS_Registry

2609-46-3

CHEBI_ID

CHEBI:2639

Chemical_Formula

C6H8ClN7O

code

C61633

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels located in the distal tubules and collecting ducts of the kidney, thereby preventing the absorption of sodium and increasing its excretion along with water, to produce naturesis. In response to the hypernatremic conditions in the kidney, the plasma membrane becomes hyperpolarized and electrochemical forces are reduced, which then prevents the excretion of potassium and hydrogen into the lumen.

FDA_UNII_Code

7DZO8EB0Z3

FULL_SYN

AMILORIDE

Amiloride

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47390

label

Amiloride

Legacy_Concept_Name

Amiloride

Preferred_Name

Amiloride

prefixIRI

ncit:C61633

PubMedID_Primary_Reference

9563749

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0002502

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C582

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49186

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http://purl.bioontology.org/ontology/CSP/2507-2912 CRISP LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147699 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/LP16024-9 LOINC LOOM
http://www.drugbank.ca/drugs/DB00594 FTC LOOM
http://purl.bioontology.org/ontology/UATC/C03DB01 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4019603 VANDF LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#amiloride FASTO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU006775 LOINC LOOM
http://purl.bioontology.org/ontology/SNMI/C-72410 SNMI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/87395005 SNOMEDCT LOOM
http://www.co-ode.org/ontologies/galen#Amiloride GALEN LOOM
http://purl.jp/bio/4/id/200906066759071490 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D000584 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_2639 GO-PLUS LOOM
http://id.loc.gov/authorities/subjects/sh85004476 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/RXNORM/644 RXNORM LOOM
http://purl.bioontology.org/ontology/RCD/x01Qu RCD LOOM
http://purl.bioontology.org/ontology/NDDF/004861 NDDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387503008 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.679.149 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D000584 MESH LOOM
http://bmi.utah.edu/ontologies/hfontology/C0002502 HFO LOOM