National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Amantadine

Synonyms

Amantadine

AMANTADINE

Definitions

A synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells. Furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61632

CAS_Registry

768-94-5

CHEBI_ID

CHEBI:2618

Chemical_Formula

C10H17N

code

C61632

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells. Furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.

FDA_UNII_Code

BF4C9Z1J53

FULL_SYN

Amantadine

AMANTADINE

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C90781

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28818

label

Amantadine

Legacy_Concept_Name

Amantadine

Preferred_Name

Amantadine

prefixIRI

ncit:C61632

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0002403

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C93038

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38149

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C281

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http://stirdf.jst.go.jp/id/200907049051921908 IOBC LOOM
http://doe-generated-ontology.com/OntoAD#C0002403 ONTOAD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#968 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/620 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.100.050.035 RH-MESH LOOM
http://purl.bioontology.org/ontology/CSP/0779-3475 CRISP LOOM
http://purl.bioontology.org/ontology/RCD/x01Bl RCD LOOM
http://purl.bioontology.org/ontology/LNC/MTHU006774 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_2618 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_2618 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_2618 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2618 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_2618 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_2618 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_2618 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2618 NIFSTD LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147697 ODAE LOOM
http://purl.bioontology.org/ontology/UATC/N04BB01 ATC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Amantadine APAONTO LOOM
http://purl.jp/bio/4/id/200906074569225078 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-55B20 SNMI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0002403 OCHV LOOM
http://scai.fraunhofer.de/MSOntology#Amantadine MSO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D000547 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147697 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/LP14353-4 LOINC LOOM
http://www.drugbank.ca/drugs/DB00915 FTC LOOM
http://www.semanticweb.org/ontologies/2011/1/Ontology1296772722296.owl#EPO_00000062 PDON LOOM
http://purl.bioontology.org/ontology/MESH/D000547 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372763006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4019601 VANDF LOOM