National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Amikacin

Synonyms

AMIKACIN

amikacin

Amikacin

Definitions

A broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically locking 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61615

ALT_DEFINITION

An antibiotic drug used to treat infection. It belongs to the family of drugs called aminoglycoside antibiotics.

CAS_Registry

37517-28-5

CHEBI_ID

CHEBI:2637

Chemical_Formula

C22H43N5O13

code

C61615

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically locking 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria.

FDA_UNII_Code

84319SGC3C

FULL_SYN

AMIKACIN

amikacin

Amikacin

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C230

label

Amikacin

Legacy_Concept_Name

Amikacin_Base

Preferred_Name

Amikacin

prefixIRI

ncit:C61615

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0002499

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2363

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/UATC/S01AA21 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D09.408.051.476.060 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D000583 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387266001 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/641 RXNORM LOOM
http://purl.bioontology.org/ontology/UATC/D06AX12 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147698 NDFRT LOOM
http://purl.bioontology.org/ontology/SNMI/C-52520 SNMI LOOM
http://purl.bioontology.org/ontology/NDDF/004899 NDDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#1001 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002886 LOINC LOOM
http://purl.bioontology.org/ontology/VANDF/4019602 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/LP15005-9 LOINC LOOM
http://purl.obolibrary.org/obo/ARO_0000013 ARO LOOM
http://purl.bioontology.org/ontology/UATC/J01GB06 ATC LOOM
http://purl.bioontology.org/ontology/CPT/80150 CPT LOOM
http://purl.jp/bio/4/id/200906020001206645 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D000583 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0002499 OCHV LOOM
http://stirdf.jst.go.jp/id/200907084160026200 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_2637 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_2637 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_2637 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_2637 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2637 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_2637 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_2637 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_2637 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_2637 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_2637 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_2637 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_2637 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_2637 NIFSTD LOOM
http://www.co-ode.org/ontologies/galen#Amikacin GALEN LOOM
http://purl.bioontology.org/ontology/RCD/e82.. RCD LOOM