loading...| Preferred Name |
Posaconazole |
|
| Synonyms |
Posaconazole POSACONAZOLE Noxafil SCH 56592 |
|
| Definitions |
A broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61500 |
|
| Accepted_Therapeutic_Use_For |
Fungal Infection Prevention for Immunocompromised Host |
|
| CAS_Registry |
171228-49-2 |
|
| CHEBI_ID |
CHEBI:64355 |
|
| Chemical_Formula |
C37H42F2N8O4 |
|
| code |
C61500 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase. |
|
| Display_Name |
Posaconazole |
|
| FDA_UNII_Code |
6TK1G07BHZ |
|
| FULL_SYN |
Posaconazole POSACONAZOLE Noxafil SCH 56592 |
|
| label |
Posaconazole |
|
| Legacy Concept Name |
Posaconazole |
|
| NCI_Drug_Dictionary_ID |
361793 |
|
| PDQ_Closed_Trial_Search_ID |
361793 |
|
| PDQ_Open_Trial_Search_ID |
361793 |
|
| Preferred_Name |
Posaconazole |
|
| prefixIRI |
Thesaurus:C61500 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0936148 |
|
| subClassOf |