loading...| Preferred Name |
Levodopa |
|
| Synonyms |
3-Hydroxy-L-tyrosine L-.beta.-(3,4-Dihydroxyphenyl)alanine (--)-3-(3,4-Dihydroxyphenyl)-L-alanine (--)-2Amino-3-(3,4-dihydroxyphenyl)propanoic Acid (-)-3-(3,4-Dihydroxyphenyl)-L-alanine 3-(3,4-Dihydroxyphenyl)-L-alanine .beta.-(3,4-Dihydroxyphenyl)-L-alanine beta-(3,4-Dihydroxyphenyl)-L-alanine Bendopa Cidandopa Deadopa Dopaflex Dopaidan Dopal Dopalina Dopar Doparkine Doparl Dopasol Dopaston Dopastral Doprin Eldopal Eldopar Eldopatec Eurodopa L(-)-Dopa L-DOPA L-Dopa LEVODOPA Laradopa Larodopa Ledopa Levodopa Levopa Maipedopa Parda Veldopa |
|
| Definitions |
An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson's disease. To assure that adequate concentrations of levodopa reach the central nervous system, it is administered with carbidopa, a decarboxylase inhibitor that does not cross the blood-brain barrier, thereby diminishing the decarboxylation and inactivation of levodopa in peripheral tissues and increasing the delivery of dopamine to the CNS. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C611 |
|
| CAS_Registry |
59-92-7 |
|
| CHEBI_ID |
CHEBI:15765 |
|
| Chemical_Formula |
C9H11NO4 |
|
| code |
C611 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson's disease. To assure that adequate concentrations of levodopa reach the central nervous system, it is administered with carbidopa, a decarboxylase inhibitor that does not cross the blood-brain barrier, thereby diminishing the decarboxylation and inactivation of levodopa in peripheral tissues and increasing the delivery of dopamine to the CNS. |
|
| FDA_UNII_Code |
46627O600J |
|
| FULL_SYN |
3-Hydroxy-L-tyrosine L-.beta.-(3,4-Dihydroxyphenyl)alanine (--)-3-(3,4-Dihydroxyphenyl)-L-alanine (--)-2Amino-3-(3,4-dihydroxyphenyl)propanoic Acid (-)-3-(3,4-Dihydroxyphenyl)-L-alanine 3-(3,4-Dihydroxyphenyl)-L-alanine .beta.-(3,4-Dihydroxyphenyl)-L-alanine beta-(3,4-Dihydroxyphenyl)-L-alanine Bendopa Cidandopa Deadopa Dopaflex Dopaidan Dopal Dopalina Dopar Doparkine Doparl Dopasol Dopaston Dopastral Doprin Eldopal Eldopar Eldopatec Eurodopa L(-)-Dopa L-DOPA L-Dopa LEVODOPA Laradopa Larodopa Ledopa Levodopa Levopa Maipedopa Parda Veldopa |
|
| label |
Levodopa |
|
| Legacy Concept Name |
Levodopa |
|
| NCI_Drug_Dictionary_ID |
42622 |
|
| NSC Number |
118381 |
|
| PDQ_Closed_Trial_Search_ID |
42622 |
|
| PDQ_Open_Trial_Search_ID |
42622 |
|
| Preferred_Name |
Levodopa |
|
| prefixIRI |
Thesaurus:C611 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0023570 |
|
| subClassOf |