National Cancer Institute Thesaurus

Last uploaded: November 25, 2019
Preferred Name

Ketoconazole

Synonyms

Panfungol

Fungoral

Ketoderm

Xolegel

ketoconazole

Ketoconazole

Nizoral

Fungarest

KETOCONAZOLE

Ketoisdin

Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine

R-41400

Orifungal M

Definitions

A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C605

Accepted_Therapeutic_Use_For

Seborrheic Dermatitis; Prostate cancer

ALT_DEFINITION

A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones.

CAS_Registry

65277-42-1

CHEBI_ID

CHEBI:47519

Chemical_Formula

C26H28Cl2N4O4

code

C605

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04)

Display_Name

Ketoconazole

FDA_UNII_Code

R9400W927I

FULL_SYN

Panfungol

Fungoral

Ketoderm

Xolegel

ketoconazole

Ketoconazole

Nizoral

Fungarest

KETOCONAZOLE

Ketoisdin

Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine

R-41400

Orifungal M

label

Ketoconazole

Legacy_Concept_Name

Ketoconazole

NSC_Code

317629

PDQ_Closed_Trial_Search_ID

39488

PDQ_Open_Trial_Search_ID

39488

Preferred_Name

Ketoconazole

prefixIRI

ncit:C605

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0022625

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2018

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C254

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http://purl.bioontology.org/ontology/SNOMEDCT/387216007 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/6135 RXNORM LOOM
http://purl.bioontology.org/ontology/UATC/J02AB02 ATC LOOM
http://purl.bioontology.org/ontology/UATC/G01AF11 ATC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002299 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0022625 OCHV LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 TXPO LOOM
http://purl.bioontology.org/ontology/NDDF/002903 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007654 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/x02Lx RCD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#7076 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D007654 MESH LOOM
http://purl.jp/bio/4/id/200906042931697847 IOBC LOOM
http://purl.obolibrary.org/obo/dinto_DB01026 DINTO LOOM
http://stirdf.jst.go.jp/id/200907037443118773 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.606.560 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP15862-3 LOINC LOOM
http://purl.bioontology.org/ontology/CSP/1549-4550 CRISP LOOM
http://purl.bioontology.org/ontology/SNMI/C-52B50 SNMI LOOM
http://purl.obolibrary.org/obo/CHEBI_48339 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_48339 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_48339 DIDEO LOOM
http://purl.bioontology.org/ontology/UATC/D01AC08 ATC LOOM
http://www.bioassayontology.org/bao#BAO_0000796 BAO LOOM
http://purl.bioontology.org/ontology/VANDF/4019271 VANDF LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039488 PDQ LOOM
http://www.co-ode.org/ontologies/galen#Ketoconazole GALEN LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147470 NDFRT LOOM