National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Ketoconazole

Synonyms

Ketoconazole

Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine

Orifungal M

ketoconazole

KETOCONAZOLE

Fungarest

Fungoral

Ketoderm

Ketoisdin

Nizoral

Panfungol

R-41400

Xolegel

Definitions

A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C605

Accepted_Therapeutic_Use_For

Seborrheic Dermatitis; Prostate cancer

ALT_DEFINITION

A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones.

CAS_Registry

65277-42-1

CHEBI_ID

CHEBI:47519

Chemical_Formula

C26H28Cl2N4O4

code

C605

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192234

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

HemOnc

OORO

DEFINITION

A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. (NCI04)

Display_Name

Ketoconazole

FDA_UNII_Code

R9400W927I

FULL_SYN

Ketoconazole

Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine

Orifungal M

ketoconazole

KETOCONAZOLE

Fungarest

Fungoral

Ketoderm

Ketoisdin

Nizoral

Panfungol

R-41400

Xolegel

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Ketoconazole

Legacy Concept Name

Ketoconazole

Maps_To

Ketoconazole

NCI_Drug_Dictionary_ID

39488

NSC Number

317629

PDQ_Closed_Trial_Search_ID

39488

PDQ_Open_Trial_Search_ID

39488

Preferred_Name

Ketoconazole

prefixIRI

Thesaurus:C605

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0022625

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C254

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2018

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_47519 FYPO LOOM
http://purl.bioontology.org/ontology/MESH/D007654 MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147470 NDFRT LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039488 PDQ LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387216007 SNOMEDCT LOOM
https://go.drugbank.com/drugs/DB01026 MDM LOOM
http://purl.bioontology.org/ontology/ATC/H02CA03 ATC LOOM
http://www.co-ode.org/ontologies/galen#Ketoconazole GALEN LOOM
http://purl.bioontology.org/ontology/ATC/J02AB02 ATC LOOM
http://purl.obolibrary.org/obo/ARO_3007517 ARO LOOM
http://purl.bioontology.org/ontology/ATC/G01AF11 ATC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002299 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007654 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018270 PMAPP-PMO LOOM
http://purl.jp/bio/4/id/200906042931697847 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0022625 OCHV LOOM
http://purl.bioontology.org/ontology/NDDF/002903 NDDF LOOM
http://purl.bioontology.org/ontology/ATC/D01AC08 ATC LOOM
http://purl.bioontology.org/ontology/RXNORM/6135 RXNORM LOOM
http://purl.bioontology.org/ontology/CSP/1549-4550 CRISP LOOM
http://purl.obolibrary.org/obo/MESH_D007654 BERO LOOM
http://stirdf.jst.go.jp/id/200907037443118773 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-52B50 SNMI LOOM
http://purl.obolibrary.org/obo/OMIT_0008762 OMIT LOOM
http://purl.bioontology.org/ontology/LNC/LP15862-3 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#7076 OCHV LOOM
http://purl.bioontology.org/ontology/RCD/x02Lx RCD LOOM
http://purl.obolibrary.org/obo/NCIT_C605 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.606.560 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_48339 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_48339 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_48339 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_48339 DIDEO LOOM
http://purl.obolibrary.org/obo/dinto_DB01026 DINTO LOOM
http://purl.bioontology.org/ontology/VANDF/4019271 VANDF LOOM
http://www.bioassayontology.org/bao#BAO_0000796 BAO LOOM