National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Isotretinoin

Synonyms

Neovitamin A

13-cis retinoic acid

Isotretinoinum

13-cis-Retinoic Acid

13-cis-Vitamin A Acid

ISOTRETINOIN

3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid

Isotretinoin

13-cis-Retinoate

cis-Retinoic Acid

Retinoicacid-13-cis

Neovitamin A Acid

isotretinoin

13-cRA

Absorica

Accure

Accutane

Amnesteem

Cistane

Claravis

Isotrex

Isotrexin

Myorisan

Oratane

Ro 4-3780

Ro-4-3780

Roaccutan

Roaccutane

Roacutan

Sotret

ZENATANE

Definitions

A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C603

Accepted_Therapeutic_Use_For

Severe recalcitrant nodular acne; psoriasis; cornification disorders; cutaneous T-cell lymphoma; juvenile metastatic neuroblastoma and leukemia

ALT_DEFINITION

A drug that is used in the treatment of acne and psoriasis and is being studied in cancer prevention. It is a type of retinoid.

CAS_Registry

4759-48-2

CHEBI_ID

CHEBI:6067

Chemical_Formula

C20H28O2

code

C603

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

HemOnc

DEFINITION

A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.

Display_Name

Isotretinoin

FDA_UNII_Code

EH28UP18IF

FULL_SYN

Neovitamin A

13-cis retinoic acid

Isotretinoinum

13-cis-Retinoic Acid

13-cis-Vitamin A Acid

ISOTRETINOIN

3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid

Isotretinoin

13-cis-Retinoate

cis-Retinoic Acid

Retinoicacid-13-cis

Neovitamin A Acid

isotretinoin

13-cRA

Absorica

Accure

Accutane

Amnesteem

Cistane

Claravis

Isotrex

Isotrexin

Myorisan

Oratane

Ro 4-3780

Ro-4-3780

Roaccutan

Roaccutane

Roacutan

Sotret

ZENATANE

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17534

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17532

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Isotretinoin

Legacy Concept Name

Isotretinoin

Maps_To

Isotretinoin

NCI_Drug_Dictionary_ID

42657

NSC Number

329481

PDQ_Closed_Trial_Search_ID

42657

PDQ_Open_Trial_Search_ID

42657

Preferred_Name

Isotretinoin

prefixIRI

Thesaurus:C603

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0022265

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C804

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/XCO_0000469 XCO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D23.767.261.700.325 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#IsoTretinoin GALEN LOOM
http://purl.bioontology.org/ontology/VANDF/4017801 VANDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0022265 OCHV LOOM
http://purl.bioontology.org/ontology/ATC/D10AD04 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015474 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.849.131.495.325 RH-MESH LOOM
http://www.gamuts.net/entity#isotretinoin GAMUTS LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042657 PDQ LOOM
http://purl.bioontology.org/ontology/MESH/D015474 MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146162 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/LP17250-9 LOINC LOOM
http://purl.obolibrary.org/obo/MESH_D015474 BERO LOOM
http://purl.bioontology.org/ontology/ATC/D10BA01 ATC LOOM
http://purl.obolibrary.org/obo/OMIT_0016217 OMIT LOOM
http://purl.obolibrary.org/obo/NCIT_C603 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.326.271.665.202.495.325 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/m72.. RCD LOOM
https://go.drugbank.com/drugs/DB00982 MDM LOOM
http://purl.bioontology.org/ontology/NLMVS/2.16.840.1.113883.3.464.1003.196.12.1143 NLMVS LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6974 OCHV LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387208003 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_6067 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_6067 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_6067 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_6067 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6067 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_6067 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_6067 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_6067 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6067 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6067 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6067 NIFSTD LOOM
http://purl.bioontology.org/ontology/SNMI/C-90050 SNMI LOOM
http://www.drugbank.ca/drugs/DB00982 FTC LOOM
http://purl.bioontology.org/ontology/RXNORM/6064 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.392.368.367.379.249.700.325 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016678 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060990 LOINC LOOM