Preferred Name

Isoniazid

Synonyms

Isonicotinyl Hydrazine

ISONIAZID

Isoniazid

Isonicotinic Acid Hydrazide

Definitions

A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to block the synthesis of mycolic acids, major components of the mycobacterial cell wall. This agent is only active against actively growing mycobacteria because, as a pro-drug, it requires activation in susceptible mycobacterial species. Isoniazid also interferes with mycobacterial metabolism of vitamin B6. Resistance occurs due to decreased bacterial wall penetration. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C600

CAS_Registry

54-85-3

CHEBI_ID

CHEBI:6030

Chemical_Formula

C6H7N3O

code

C600

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to block the synthesis of mycolic acids, major components of the mycobacterial cell wall. This agent is only active against actively growing mycobacteria because, as a pro-drug, it requires activation in susceptible mycobacterial species. Isoniazid also interferes with mycobacterial metabolism of vitamin B6. Resistance occurs due to decreased bacterial wall penetration. (NCI04)

FDA_UNII_Code

V83O1VOZ8L

FULL_SYN

Isonicotinyl Hydrazine

ISONIAZID

Isoniazid

Isonicotinic Acid Hydrazide

label

Isoniazid

Legacy_Concept_Name

Isoniazid

NSC_Code

9659

PDQ_Closed_Trial_Search_ID

39484

PDQ_Open_Trial_Search_ID

39484

Preferred_Name

Isoniazid

prefixIRI

ncit:C600

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0022209

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C280

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http://purl.bioontology.org/ontology/SNMI/C-55260 SNMI LOOM
http://purl.bioontology.org/ontology/LNC/MTHU008094 LOINC LOOM
http://www.co-ode.org/ontologies/galen#Isoniazid GALEN LOOM
http://scai.fraunhofer.de/HuPSON#SCAIVPH_00001317 HUPSON LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Isoniazid APAONTO LOOM
http://purl.bioontology.org/ontology/RCD/ed4.. RCD LOOM
http://purl.bioontology.org/ontology/VANDF/4017505 VANDF LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039484 PDQ LOOM
http://bmi.utah.edu/ontologies/hfontology/C0022209 HFO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.725.394.582 RH-MESH LOOM
http://localhost/plosthes.2017-1#10068 PLOSTHES LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145890 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387472004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDDF/002844 NDDF LOOM
http://purl.bioontology.org/ontology/LNC/LP15831-8 LOINC LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005880 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005880 DMTO LOOM
http://purl.bioontology.org/ontology/UATC/J04AC01 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007538 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D007538 MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/6038 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.066.349.410 RH-MESH LOOM
http://scai.fraunhofer.de/MSOntology#Isoniazid MSO LOOM
http://purl.bioontology.org/ontology/CSP/0316-4065 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.442.436 RH-MESH LOOM
http://purl.obolibrary.org/obo/dinto_DB00951 DINTO LOOM