loading...| Preferred Name |
Isoniazid |
|
| Synonyms |
Isonicotinic Acid Hydrazide Isonicotinyl Hydrazine ISONIAZID Isoniazid |
|
| Definitions |
A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to block the synthesis of mycolic acids, major components of the mycobacterial cell wall. This agent is only active against actively growing mycobacteria because, as a pro-drug, it requires activation in susceptible mycobacterial species. Isoniazid also interferes with mycobacterial metabolism of vitamin B6. Resistance occurs due to decreased bacterial wall penetration. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C600 |
|
| CAS_Registry |
54-85-3 |
|
| CHEBI_ID |
CHEBI:6030 |
|
| Chemical_Formula |
C6H7N3O |
|
| code |
C600 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to block the synthesis of mycolic acids, major components of the mycobacterial cell wall. This agent is only active against actively growing mycobacteria because, as a pro-drug, it requires activation in susceptible mycobacterial species. Isoniazid also interferes with mycobacterial metabolism of vitamin B6. Resistance occurs due to decreased bacterial wall penetration. (NCI04) |
|
| FDA_UNII_Code |
V83O1VOZ8L |
|
| FULL_SYN |
Isonicotinic Acid Hydrazide Isonicotinyl Hydrazine ISONIAZID Isoniazid |
|
| label |
Isoniazid |
|
| Legacy Concept Name |
Isoniazid |
|
| NCI_Drug_Dictionary_ID |
39484 |
|
| NSC Number |
9659 |
|
| PDQ_Closed_Trial_Search_ID |
39484 |
|
| PDQ_Open_Trial_Search_ID |
39484 |
|
| Preferred_Name |
Isoniazid |
|
| prefixIRI |
Thesaurus:C600 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0022209 |
|
| subClassOf |